Phase 4 N=29 Trial of Levomilnacipran in Geriatric Depression
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale (HDRS) Scores 24 — 17.88; 19.92; 6.86; 10.33 units on a scale
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=17 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2
Japanese Encephalitis · Japanese Encephalitis Vaccine
Primary: Change of T Lymphocyte Responses to Live Attenuated JE SA-14-14-2 Vaccine at Week 2. — 34 IFNγ SFC/million PBMC
Phase 4 N=10 Functional Effects of Botox on the Brain Using MRS and fMRI
Healthy
Primary: Glutamate + Glutamine (Glx)/Creatine Ratio as Measured by MRS in the Brainstem Pre and Post-Botox — .12 Brainstem GLX/Cr
Phase 4 N=121 Hydrocodone For Pain Control in First Trimester Surgical Abortion
Pain
Primary: Patient Perception of Pain — 65.7; 63.1 mm
Phase 4 N=479 Safety of Nasal Influenza Immunisation in Children With Asthma
Asthma
Primary: Change in Asthma Symptoms and Control Pre and 4 Weeks Post LAIV, as Assessed by Validated Questionnaire — 28; 254; 37 Participants — p=0.26
Phase 4 N=20 Immune Response Following Seasonal Influenza Vaccination
Influenza
Primary: HAI Antibody Immune Response to Matched Influenza Strain H1N1 A/California/04/2009 Strain — 293.4 Geometric Mean Titer
Phase 4 N=623 A Comparative Effectiveness RCT of Optimized Cessation Treatments
Smoking Cessation
Primary: Number of Participants With Abstinence From Smoking — 19; 49 Participants — p=<.001
Phase 4 N=135 Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) Treatment
Major Depression
Primary: Montgomery-Asberg's Depression Rating Scale — 9.2 score on a scale
Phase 4 N=78 Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta
Osteogenesis Imperfecta
Primary: Spine Bone Mineral Density (BMD) — 6.1; 2.8 percentage of change in g/cm2
Phase 4 N=39 Study to Evaluate the Safety and Efficacy of Daclatasvir/Sofosbuvir/Ribavirin for 16 Versus 24 Weeks for HCV Genotype 3 Cirrhotics
Hepatitis C · Cirrhosis
Primary: Number of Participants With Adverse Events — 21; 18 Participants
Phase 4 N=96 A Comparative Evaluation of the Performance and Fit of Pediatric Face Masks
Healthy
Primary: Change From Baseline in Carbon Dioxide Levels — -0.07; -0.79 mmHg
Phase 4 N=226 Stress Neuroadaptation in Tobacco Dependence
Nicotine Dependence
Primary: Overall Stressor Reactivity — 25.1; 22.5; 32.3; 16.9 microvolts
Phase 4 N=66 Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque
Atrial Fibrillation
Primary: Coronary Artery Calcium (CAC) Score — 66; 31 units on a scale
Phase 4 N=199 Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants
Primary Open Angle Glaucoma
Primary: Change From Baseline in Mean Intraocular Pressure (IOP) in the Study Eye to Month 12 — 21.7; 21.0; -6.6; -6.4 mmHg
Phase 4 N=91 Tocilizumab Real-Life Human Factors (RLHFs) Validation Study
Rheumatoid Arthritis
Primary: Percentage of Participants Who Successfully Performed Safety-Critical and Essential Tasks During First Unassisted Use — 100.00; 100.00; 100.00; 100.00 percentage of…