Phase 2 N=42 Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer
Colon Adenocarcinoma · Rectal Adenocarcinoma · Recurrent Colon Carcinoma
Primary: To Examine the DLT — 200 mg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=69 Dorsal Root Ganglion Thermal Radiofrequency Versus Pulsed Radiofrequency for Metastatic Pain in Thoracic Vertebral Body
Bone Neoplasm,Malignant Vertebral Column Thoracic Secondary
Primary: The European Organisation for Research and Treatment of Cancer (EORTC) Questionnaire to Measure Change in the Intensity of Pain QLQ-C30 — 41.30; 51.08; 38.76; 42.48…
Phase 3 N=270 Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Agitation Associated With · Alzheimer's Disease · Alzheimer's Type
Primary: Change From Baseline to Week 12/Early Termination in the Cohen-Mansfield Agitation Inventory (CMAI) Total Score — -18.9; -16.5 units on a scale — p==0.1454
N/A N=2,004 A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia
Dengue
Primary: Incidence Rate of Acute Febrile Illness (AFI) Due to Laboratory Confirmed Dengue (LCD) Overall, and by Age Group — 21.25; 22.69; 12.76; 9.16 Person-year rate ( Per 1000)
Phase 3 N=267 Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE)
Venous Thromboembolism
Primary: Composite Primary Endpoint — 81; 38; 170; 83 Participants — p== 0.0001
Phase 2 N=125 Evaluation Of Aqueous Humor Of Levofloxacin-Dexamethasone Eye Drops And Of Its Components In Patients Undergoing Cataract Surgery
Cataract
Primary: Aqueous Humour Concentration of Levofloxacin — 1.970; 2.151; 0 nmol/mL
N/A N=67 Usability of Diabetes Dashboard Embedded Within a Patient Web Portal
Diabetes Mellitus, Type 2
Primary: Usability — 78.8 score on a scale — p=<0.001
Phase 3 N=153 Safety and Efficacy Study of a FAI Insert in Subjects With Chronic Non-infectious Posterior Uveitis
Posterior Uveitis · Intermediate Uveitis · Panuveitis
Primary: Number of Participants With Recurrence of Uveitis in Study Eye Within 6 Months — 28; 22 Participants
Phase 4 N=182 The Effects of Dexamethasone on Low Dose Interscalene Brachial Plexus Block
Shoulder Surgery · Nerve Block
Primary: Duration of Sensory Block — 521; 566 minutes
Phase 1 N=16 CS-7017 in Combination With Carboplatin/Paclitaxel in Subjects With Stage IIIb/IV Non-small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small-Cell Lung
Primary: Pharmacokinetic Parameter Area Under the Concentration Versus Time Curve of Geometric Means of Serum Free Form of CS-7017 (R-150033) After Administration of CS-7017 and…
N/A N=229 Enhanced Medical Rehabilitation in Older Adults
Disabling Medical Events · Disabled · Depression
Primary: Change in Barthel Index Score — 28.48; 34.92 score on a scale — p=0.007
Phase 3 N=2,464 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention
Pregnancy Complications · Preeclampsia
Primary: Preeclampsia — 169; 156 Participants — p=0.37
Phase 3 N=1,645 Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
Acute Myeloid Leukemia · Leukemia Cutis · Myeloid Neoplasm
Primary: Event-free Survival (EFS) for Patients Without High Allelic Ratio FLT3/ITD+ Mutations — 45.64; 46.95 percentage of patients
N/A N=31 Radiation Dose Escalation in Esophageal Cancer
Esophageal Cancer
Primary: Number of Dose Limiting Toxicities (DLTs) Occurring in Participants — 0; 0; 0; 1 dose limiting toxicity
N/A N=517 Study of the Penumbra Coil 400 System to Treat Aneurysm
Intracranial Aneurysms · Peripheral Aneurysms
Primary: Packing Density With the Number of Coils Implanted — 37.9 percentage of aneurysm volume