Phase 2 N=250 Analgesic Effect of IV Acetaminophen in Tonsillectomies
Adenotonsillitis · Tonsillitis
Primary: FLACC Pain Score Greater Than or Equal to 4 — 58; 69 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=105 Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.
Nephrolithiasis
Primary: Satisfaction With Pain Relief — 8.70; 8.85 score on a scale — p=0.70
Phase 4 N=100 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery
Opioid Use
Primary: Amount of Pain Experienced — 28; 35 Score on a scale
Phase 4 N=73 Pre-emptive Analgesics in Orthodontic Treatment
NSAID · Pain Management
Primary: Visual Analog Scale (VAS) Pain Scores at 6 Hours After Treatment — 0.6; 2.6; 1.0; 2.0 scores on a scale — p=0.04
N/A N=178 Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Lumbar Osteoarthritis · Spondylosis · Lumbar Disc Disease
Primary: Perioperative Opioid Use — 86.25; 306.6; 192.4; 88.95 oral morphine equivalents (OME) (mmg) — p=<0.001
Phase 2 N=115 Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Dental Pain
Primary: Sum Pain Intensity Difference Scores — -2.4292; -68.0778; -68.3533; -93.3645 score on a scale
Early Phase 1 N=114 Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
Pain, Postoperative · Analgesia
Primary: Postoperative Pain, as Measured by Wong-Baker Facial Rating Pain Scale ,After Routine Dental Treatment — 20; 20; 7; 11 Participants
Phase 3 N=105 Analgesic Effect of Peripheral Dexmedetomidine
Third Molar Extraction
Primary: Pain Score at Rest — 165.5; 218.2; 233.8 score on a scale×hr
N/A N=54 Analgesic Efficacy After Umbilical Hernia Repair in Children
Umbilical Hernia
Primary: The Amount of Intravenous and Oral Opioids Used by Patients Who Receive a Rectus Sheath Nerve Block and Those Who Receive Local Infiltration of the Surgical Site for…
Phase 4 N=416 Comparative Efficacy of 4 Oral Analgesics
Pain
Primary: Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores — 4.4; 3.5; 3.9; 4.3 units on a scale
Phase 3 N=321 Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction
Acute Pain
Primary: Ranked Endpoints : 1. Sum of Pain Intensity Differences at 6 Hours (SPID0-6h) — 8955.4; 8458.0; 5290.7 score on a scale — p=0.0031
Phase 4 N=172 Opioid Analgesia for MAB
MAB · Pain
Primary: Overall Maximum Self-reported Pain Score — 8; 8 units on a scale
Phase 4 N=85 Multimodal Analgesia With Acetaminophen vs. Narcotics Alone After Hip Arthroscopy
Hip Arthroscopy
Primary: Patient Satisfaction — 8.48; 8.83 score on a scale
Phase 2 N=38 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
Healthy
Primary: Cumulative Stress Index — 647; 676 mmHg x minutes
Early Phase 1 N=46 Pain Management in Teeth With Reversible Pulpitis
Reversible Pulpitis · Ibuprofen
Primary: Change in Pain Intensity From Baseline (Pre-Operative) to Immediately During the Procedure (Day 0), Measured by the Visual Analogue Scale (VAS) — 5.05; 0.64 score on a…
N/A N=501 Oral Analgesic Utilization for CHildhood Musculoskeletal Injuries
Musculoskeletal Injury
Primary: Pain Intensity - Percentage of Children Who Achieved VAS < 30 mm — 33.0; 29.3; 29.9 Percentage of participants — p=0.81
Phase 4 N=119 Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
Pain, Postoperative
Primary: Postoperative Pain Levels — 1.3160; 2.1362 score on a scale
Phase 4 N=100 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery
Postoperative Pain
Primary: Number of Patients Requiring Rescue Medication — 29; 36 patients
N/A N=36 Preoperative Gabapentin for Post-tonsillectomy Pain in Children
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Primary: Total Oral Analgesia Consumption — 0.228; 0.224; 0.200; 0.193 cumulative hydrocodone (mg/kg)
Phase 4 N=170 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section
Opioid Use · Pain, Postoperative
Primary: Pain Level — 12.3; 15.9 millimeters on a scale
Phase 2 N=600 Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
Musculoskeletal Pain
Primary: Change in Pain From Before Medication Administered (Baseline) to One-hour Post-baseline — 3.0; 3.0; 3.4; 3.1 Units on a scale — p=0.69
Phase 3 N=162 IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients
Acute Pain
Primary: Change in Numerical Rating Scale of Pain (NRS) Before Treatment to 60 Minutes After Treatment — 6.2; 5.4 units on a scale — p=0.08
N/A N=94 Opioid Sparing Potential of Light-Induced Analgesia
Pain
Primary: Change in Pain Level — 1.15; -0.04; 1.07 score on a scale
Phase 4 N=140 Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery
Pain, Postoperative
Primary: Assessing Change in Pain Using the Visual Analogue Scale (VAS) Pain Score — 2.90; 3.51; 2.36; 2.40 score on a scale
Phase 2 N=58 Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis
Knee Osteoarthritis
Primary: Largest Change From Baseline on Clinical Pain Rating — 24.19; 30.48; 28.55; 26.38 score on a scale — p=.021
Phase 2 N=46 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Sufentanil
Healthy
Primary: Tolerance to Simulated Hemorrhage — 599; 651 min*mmHg
Phase 4 N=66 IV Acetaminophen for Acute Post Operative Pain in C-Section Patients
Post-operative Pain
Primary: Opioid Requirements in Cesarean Section (C-section) Patient Population — 44; 48; 58; 57 mg
N/A N=160 Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management
Postoperative Pain
Primary: Opioid Consumption in the 0-48 Hour Study Periods. — 10; 5; 10; 5 milligram morphine equivalents (MMEQ)
Phase 4 N=65 Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
Pain, Postoperative
Primary: Pain as Assessed by a Visual Analogue Scale (VAS) — 4; 2.33 score on a scale
Phase 4 N=167 Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures
Femur Fracture · Tibial Fractures
Primary: 12hrs VAS Pain Scores — 7.6; 7.9; 7.3; 7.2 score on a scale — p=0.215