Phase 4 N=35 Counseling Among Gender Diverse Adolescents Who Use Depot Medroxyprogesterone
Gender Dysphoria, Adolescent
Primary: Number of Participants Satisfied With Self-Administered DMPA at Initiation — 17 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=48 Group Depression Treatment for Autistic Youth
Autism Spectrum Disorder · Depression · Suicidal Ideation
Primary: Change in Severity of Adolescent Depressive Symptoms, Self-report — 8.14 T-score
N/A N=25 Mental Health Support for Transgender and Gender-expansive Individuals
Transgender · Depression · Anxiety
Primary: Depression: Score on the Overall Depression Severity & Impairment Scale (ODSIS) — 9.68; 4.82 score on a scale
N/A N=9 LGBTQ-affirmative CBT for Youth
Anxiety Disorders · Depression · LGBTQ
Primary: Client Satisfaction With Treatment — 27.13 score on a scale
N/A N=986 Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
Gender Dysphoria
Primary: Receipt of Gender Affirming Treatment — 769; 687; 292; 468 Participants
N/A N=223 Self-guided Treatment for Adolescents Navigating Depression
Depressive Symptoms · Depression · Depressive Disorder
Primary: Depressive Symptom Severity at Post-intervention — 8.39; 11.03 units on a scale — p=<0.001
Phase 2 N=39 Transgender Estradiol Affirming Therapy
Transgenderism
Primary: Total Testosterone Level in Transgender Female Patients — 498.6; 481.3; 505.3; 62.7 pg/mL — p=0.005
N/A N=39 Transcranial Magnetic Stimulation for Adolescent Depression
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale — 9.38 score on a scale
N/A N=20 Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
Ovarian Failure, Premature
Primary: Estradiol — 53; 14; 12 pg/mL
Phase 4 N=12 Trial of Aripiprazole in the Treatment of CD in Adolescents
Conduct Disorder
Primary: The Primary Outcome Efficacy Measure: Rating of Aggression Against People and/or Property Scale (RAAPP) (Kemph et al 1993) — 1.7 units on a scale
N/A N=186 Sibling-Support for Adolescent Girls (SSAGE)
Anxiety · Depression · Mental Illness
Primary: Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 Level 1 Cross-Cutting Symptom — 44; 42; 24; 28 Participants
Phase 2 N=90 An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
Depressive Disorder
Primary: Children's Depression Rating Scale - Revised — 36.0; 37.5 score on a scale — p=0.76
N/A N=112 Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale-24(HAMD24) Total Score Change From Baseline Value. — -11.1; -10.6 score on a scale
N/A N=116 Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
Type 1 Diabetes Mellitus
Primary: Glycated Hemoglobin (HbA1c) — 8.84; 9.03; 9.24; 9.14 percentage of hemoglobin molecules — p=0.86
N/A N=40 Feasibility Study Comparing Standard FBT and Guided Self-Help FBT for Adolescent Anorexia Nervosa
Anorexia Nervosa
Primary: Recruitment Rate — 2.86 participants recruited per month
Phase 4 N=54 Unicirc Adolescent 12-15 Year Old Boys
Circumcision, Male
Primary: Intraoperative Duration — 9.5 minutes
N/A N=31 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism
Autism · Asperger's Syndrome · Pervasive Developmental Disorder Not Otherwise Specified
Primary: Pediatric Anxiety Rating Scale — 10.94; 13.93 units on a scale
N/A N=81 Sexual and Gender Minority Youth (SGMY) and Online Interventions to Increase Help-seeking for Anxiety and/or Depression
Anxiety · Depression · Adolescent Behavior
Primary: Feasibility - IP Use Proportion — 0.10; 0.11; 0.10; 0.08 average proportion
N/A N=42 Self-compassion Therapist-led Online Group Treatment for Adolescents With Distress, Anxiety, and Depression
Distress, Emotional · Anxiety · Depression
Primary: Perceived Stress Scale — 22.73; 20.85 units on a scale
Phase 3 N=50 The Adrenal Contribution to Androgen Production in Girls During Puberty
Development
Primary: 17-hydroxyprogesterone Response to ACTH — 2.4; 3.7; 3.1; 2.9 ng/mL
Phase 3 N=314 Dose-optimization in Adolescents Aged 13-17 Diagnosed With Attention-deficit/Hyperactivity Disorder (ADHD) Using Extended-release Guanfacine HCl
Attention-Deficit/Hyperactivity Disorder
Primary: Change From Baseline in Attention Deficit Hyperactivity Disorder Rating Scale-fourth Edition (ADHD-RS-IV) Total Score at Week 13 — -18.527; -24.552 units on a scale…
Phase 2 N=58 Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders
Mood Disorder · Disruptive Behavior Disorders
Primary: Change in Affective Reactivity Index - Youth (ARI-Y) — -2.9; -0.8 score on a scale
N/A N=36 Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Bipolar Disorder
Primary: Change From Baseline in the Tablet Routine Questionaire (TRQ) "Past Month" Item at 24 Weeks — 21.5; 28.0 percent of medications not taken
Phase 2 N=53 The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial
Endometriosis
Primary: Bone Mineral Density — 0.01; -0.11 g/cm^2 — p=0.10
N/A N=141 Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services
Depression · Anxiety
Primary: Usage Rating Profile-Intervention Revised (URP-IR), Feasibility Subscale — 30.00; 30.00 score on a scale
N/A N=172 PRISM for Adolescents With Type 1 Diabetes
Type 1 Diabetes Mellitus
Primary: A1C — 8.7; 8.6 percentage of glycosylated hemoglobin
N/A N=40 A Trial to Test an Acceptance-based Therapy Program Among Adolescent Girls With Overweight/Obesity
Weight Loss · Obesity · Overweight
Primary: BMI Change, 95th BMI Percentile (%) — -1.11; -0.08 Change in the 95th BMI percentile %
N/A N=50 Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating
Binge Eating · Eating Disorders in Adolescence · Overweight and Obesity
Primary: Binge (Loss-of-control) Eating Episode Frequency — 1.52; 6.05 episodes of behavior — p=.01
Phase 2 N=33 Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Primary: Pediatric Anxiety Rating Scale. — 11.62; 14.04 units on a scale — p=.04
Phase 3 N=8 Open-label Ziprasidone Study for Psychosis Treatment in Adolescents
Schizophreniform Disorder · Schizoaffective Disorder · Psychosis
Primary: Weight Gain and Other Side Effects