12,372 trials
Crohn Disease
Primary: Percentage of Participants With Endoscopic Response at Week 48 — 37.9; 29.9 Percentage of Participants — p== 0.0871
Heart Failure
Primary: Time to the First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF) — 21.00; 15.77 Patients with events/ 100 pt-yrs…
Homozygous Familial Hypercholesterolemia
Primary: Percent Change in Calculated Low-Density Lipoprotein Cholesterol (LDL-C) From Baseline to Week 24 (Intent-to-Treat [ITT] Estimand) — 1.9; -47.1 Percent Change — p=< 0.0001
Hepatitis C, Chronic
Primary: SVR12 — 26; 30; 17 Participants
Healthy
Primary: Area Under the Plasma Concentration-time Curve From Time Zero to Infinity(AUC0-∞) of Unchanged MT-6548 — 105.3; 100.2; 129.3; 49.2 ug*h/mL
Psoriasis
Primary: Percentage of Participants With a Static Physician Global Assessment (sPGA) Response at Week 16 During the Placebo-Controlled Phase — 4.1; 21.6 Percentage of…
Osteoarthritis
Primary: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale at Week 16: Baseline Observation Carried Forward (BOCF)…
Triple Negative Breast Cancer
Primary: Progression Free Survival (PFS) According to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1 (v1.1) in All Randomized Participants — 5.49; 7.16 Months…
Epilepsy
Primary: Change From Baseline in Weight Z-score up to Month 1 — -0.112; -0.014 Z-score
Inflammation and Pain Associated With Ocular Surgery
Primary: Subjects With an Anterior Chamber Cell Grade of 0 at Day 15 — 96; 30 Participants — p=<.0001
Allergic Conjunctivitis
Primary: Ocular Itching — 0.81; 0.79; 1.98; 1.09 score on a scale
Cancer of the Cervix
Primary: Percentage of Participants With Response Rate to Anti-Emetic Therapy Days 4-7 Each Chemotherapy Cycle — 49.8; 39.7 percentage of participants
GIST
Primary: Efficacy of Avapritinib Based on Progression-free Survival (PFS) Determined by Central Radiological Assessment Per Modified Response Evaluation Criteria in Solid Tumors…
Follicular Lymphoma
Primary: Overall Response Rate (ORR) — 87.1; 87.5 percentage
Arthritis · Osteoarthritis
Primary: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale at Week 16: Baseline Observation Carried Forward (BOCF)…