4,901 trials
Healthy Volunteers
Primary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Simvastatin and Simvastatin Acid — 6.85; 4.65; 1.93; 1.60 nanograms per milliliter (ng/mL)
Healthy Volunteers
Primary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Ethinyl Estradiol — 63.8; 59.7 picograms/milliliter (pg/mL)
Healthy Volunteers
Primary: Percentage of the Total Radioactive Dose Administered Excreted From Urine and Feces — 75.2; 19.9 percentage of total radioactivity
Healthy Volunteers
Primary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Baricitinib — 36.2; 37.3 nanograms/milliliter (ng/mL)
Healthy Volunteers
Primary: Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve During 1 Dosing Interval (AUCτ) of Digoxin — 18.7; 16.8 nanograms*hour/milliliter (ng*h/mL)
Chronic Inflammatory Disorder · Arthritis, Rheumatoid
Primary: Pharmacokinetics: Plasma Concentration-Time Curve (AUC) — 1670; 1710; 1510; 1700 nanomoles*hours per liter (nmol*h/L)
Healthy Volunteers
Primary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Baricitinib — 36.2; 35.8 nanograms/milliliter (ng/mL)
Healthy Participants
Primary: Change From Baseline Through 24 Hours Postdose in Population-Corrected QT (QTcP) Interval — -2.5; -2.4; 9.7; -1.7 milliseconds (msec)
Healthy Volunteers
Primary: PK: Maximum Concentration (Cmax) of Baricitinib — 96.1; 101 nanograms per milliliter (ng/mL)
Healthy Volunteers
Primary: Pharmacokinetics (PK): Area Under the Plasma Concentration-Time Curve From Time 0 Hour to Infinity [AUC(0-∞)] of Baricitinib Following Single Doses of Baricitinib Alone…
Hookworm Infection · Hookworm Disease
Primary: Immediate Vaccine Related Adverse Events — 4; 1; 0; 1 Participants
HIV Infections
Primary: Percentage of Participants Who Experienced a Grade 3 or Higher Systemic (i.e., Not a Local Reaction) Adverse Event (AE) That is Possibly, Probably, or Definitely Related…
Diabetes Mellitus, Type 2
Primary: Stage 1: Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast) of PF-04856883 on Day 1 — 865; 4960; 7065; 32552 nanogram*hour per milliliter…
Breast Neoplasms · Secondary · HER2 Positive Carcinoma of Breast
Primary: Test the Diagnostic Accuracy of the HER2 Imaging Using the Labelled Monoclonal Antibody Trastuzumab by Correlating the HER2 PET/CT Imaging With the FDG-PET/CT and…
Alcohol Dependence
Primary: Measure the Maximum (Peak) Plasma Concentration of the Drug (Cmax) — 8.88 ng/mL