Phase 4 N=223 Extended Treatment for Smoking Cessation
Smoking Cessation
Primary: Expired-air CO Verified Point-prevalence Abstinence — 44; 42 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=21 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
Caffeine
Primary: Intubation — 3; 7 participants
Phase 4 N=23 Medication, Weight Gain and GI Hormones
Bipolar Depression
Primary: Weight in Kilograms at Baseline, Weeks 1, 4, 6, and 8 — 76.0; 76.1; 77.4; 77.6 kilograms
Phase 4 N=50 Does Risperidone Consta Reduce Relapse and Rehospitalization in Bipolar Disorder?
Bipolar Disorder
Primary: Number of Relapse-related Events Normalized to Unit Time — 5.34; 6.26 Events/month
Phase 4 N=140 Effect of Steroid Injections in a Knee With Osteoarthritis
Osteoarthritis (OA) of the Knee
Primary: Change in Mean Cartilage Thickness in the Index Compartment (Compartment With the Most Damage) — -0.21; -0.10 mm
Phase 4 N=30 Steroids in Bilateral Total Knee Replacement
Postoperative Inflammatory Response
Primary: Decrease in IL6 Level — 359.4; 381.6 pg/ml
Phase 4 N=13 Studying the Effects of Phentermine on Eating Behavior
Obesity
Primary: Food Intake — 849; 975 kcal — p=0.26
Phase 4 N=71 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis
Facial Nerve Injuries · Facial Paresis Associated With Facial Nerve Dysfunction · Facial Asymmetry
Primary: Change in Synkinesis Assessment Questionnaire (SAQ) Scores — 45.9; 38.8; 51.3; 45.2 units on a scale
Phase 4 N=49 Effects of Simvastatin on Biomarkers
Alzheimer's Disease
Primary: Change From Baseline in Aβ42 in Cerebrospinal Fluid (CSF) at 1 Year — 5.3; 0.5 1-yr change, pg/ml — p=0.53
Phase 4 N=20 TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension
Primary: Effect of Long-term Remodulin Therapy on the 6-Minute Walk Distance (6MWD) — 440.8 Meters
Phase 4 N=12 Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis
Gastroparesis · Gastroesophageal Reflux Disease
Primary: Time to Maximal Omeprazole Concentration (Tmax) — 32; 97 minutes — p=< 0.01
Phase 4 N=125 The Efficacy and Safety Study of Rikkunshito in Patients With Functional Dyspepsia
Functional Dyspepsia
Primary: Patient's Evaluation of Symptomatic Improvement by Overall Treatment Efficacy (OTE) — 1; 5; 13; 18 Participants — p=0.038
Phase 4 N=121 Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding
Esophageal and Gastric Varices
Primary: Rebleeding From Gastric Varices — 14; 21 Participants
Phase 4 N=12 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis
COPD · Chronic Bronchitis · Emphysema
Primary: Difference in Mucociliary Clearance (MCC) Between Visit 1A and Visit 2A — -1.50; -0.70 percentage difference of MCC
Phase 4 N=25 Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit
Constipation
Primary: Presence of Small Intestinal Bacterial Overgrowth — 8; 9 Participants — p=0.75