Phase 1 N=27 HEMOBLAST Pilot Clinical Investigation
Hemostasis
Primary: Mean Paired Kappa Statistic for the Assignment of SBSS Scores by 2 Investigators — 0.7754 Kappa statistic
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=103 Web-based Monitoring in Children and Adolescents With Inflammatory Bowel Disease
Inflammatory Bowel Disease · Ulcerative Colitis · Crohn´s Disease
Primary: Medical Adherence — 23.3; 23.3 units on a scale — p=0.22
Phase 2 N=58 Anti-PD-1 Monoclonal Antibody in Advanced, Trastuzumab-resistant, HER2-positive Breast Cancer
Metastatic Breast Cancer
Primary: Dose-Limiting Toxicity (DLT) of MK-3475 in Combination With Trastuzumab — 0; 0 Participants
Phase 3 N=74 Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study
Visceral Leishmaniosis · HIV-infection/Aids
Primary: Probability of Relapse-free Survival — 79; 71 percentage probability
N/A N=39 Efficacy of Glaucoma Drop Aids in Medication Compliance in the Patient Population at Boston Medical Center
Glaucoma
Primary: Number of Participants Assessed for Intraocular Pressure Change — 0; 4; 4; 8 Participants
Phase 2 N=100 A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part B: Caucasian Participants (P05971)
Anesthesia, General
Primary: Time From Start of Administration of Sugammadex or Placebo to Recovery of the Fourth Twitch/First Twitch (T4/T1) Ratio to 0.9 — 96.30; 16.30; 4.62; 1.43 Minutes
Phase 4 N=137 Single Dose Preoperative Gabapentin Use in Minimally Invasive Hysterectomy for Acute Pain Management
Pain, Postoperative
Primary: Narcotic Use at 24 Hours Postop — 158.8; 175.0 morphine milligram equivalents
N/A N=85 Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Adult Volunteers
Pre Eclampsia
Primary: Accuracy of Blood Pressure Measurement by Sphygmo Relative to the Clinical Standard. — 122.5; 74.5; 123.1; 72.1 mmHg
Phase 1 N=37 Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)
Critically Ill · Pneumonia
Primary: Maximum Plasma Concentration (Cmax) of Ceftolozane or Tazobactam in Mechanically Ventilated Participants for the First and Last Dose of Ceftolozane/Tazobactam Treatment…
Phase 4 N=103 Safety and Efficacy of Switching From Aflibercept to Ranibizumab in Patients With nAMD
Neovascular Age-related Macular Degeneration
Primary: Change in Central Subfield Retinal Thickness (CSRT) From Baseline to Day 90. — 384.00; 318.00; -30.75 micrometer — p=<0.0001
N/A N=21 Toileting at Night in Older Adults: Light to Maximize Balance, Minimize Insomnia
Falls · Balance · Insomnia
Primary: Change in Balance — 6.66; 5.34; 5.62; 5.78 %CV
Phase 4 N=16 The Effects of Sildenafil on Exercise Function and Capacity in Patients With Fontan Circulation
Fontan Circulation
Primary: The Change in Exercise Capacity Measured Via Maximum Oxygen Consumed During Exercise (VO2) — 39.4; 36.8; 41.2; 34.4 ml/min/kg
Phase 3 N=119 A Study to Compare the Efficacy of Guselkumab to Fumaric Acid Esters for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Psoriasis
Primary: Part I: Percentage of Participants Who Achieved Psoriasis Area and Severity Index (PASI) 90 Response at Week 24 — 81.7; 13.6 Percentage of Participants — p=<0.0001
N/A N=80 Initial Performance of a Modified Daily Disposable Contact Lens
Refractive Error
Primary: Incidence (Number) of Ocular Discomfort Device-related Adverse Events (AEs) — 0; 0 Eyes
Phase 3 N=1,554 An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation
Chronic Constipation · Irritable Bowel Syndrome With Constipation
Primary: Number of Participants With at Least One Treatment-Emergent Adverse Events (TEAEs) — 399; 748 Participants