65,437 trials
Tuberous Sclerosis Complex-associated Refractory Seizures
Primary: Core Phase: European Medicine Agency (EMA): Seizure Frequency Response Rate — 28.2; 40.0; 15.1 Percentage of responders — p=0.008
Open-Angle Glaucoma · Ocular Hypertension
Primary: Mean IOP — 18.61; 19.84; 18.00; 19.37 mm Hg — p=<0.01
Acute Respiratory Infection
Primary: Severity-weighted Total Days of ARI Illness — 1045; 1010; 1210 severity*days
Respiration; Insufficient or Poor, Newborn
Primary: Difference in Percentage of Leak — 35; 30 % (percentage of mass leak)
Healthy Adults (Full Study and Extension Phase) · Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
Primary: Change in Attitudes and Trust — 0.0; 0.7; 3.5; 1.8 units on a scale
Dehydration
Primary: Mean Total Volume of Fluid Administered at a Single Infusion Site, From the Start to the Cessation of Fluid Administration, for All Randomized Participants — 365.0…
Breast Adenocarcinoma · DS Stage I Plasma Cell Myeloma · DS Stage II Plasma Cell Myeloma
Primary: Percentage of Participants With at Least One Skeletal-related Event (SRE) Within 2 Years After Randomization — 67.6; 67.9 percentage of participants — p=<=.05
Recurrent Melanoma · Stage IV Melanoma
Primary: Progression-Free Survival at 4 Months — 22.2 percentage of patients
Diabetes Mellitus
Primary: Feasibility — 3; 5 Participants
Hypertension
Primary: Endothelial Cell Protein Expression p47phox From Endothelial Cell Collection — 0.47; 0.44 Ratio human to HUVEC p47Phox expression
Multiple Sclerosis
Primary: Steps Per Day
Colonoscopy Procedure
Primary: The Count and Percentage of Subjects Had Adequate Bowel Preparation After the Use of Motus Cleansing Stystem — 6; 20; 20 Participants
Respiratory Syncytial Virus Infections
Primary: Part A: Serum Concentration of Suptavumab Over Time — 280; 177; 145; 128 mg/L
Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non Small Cell Lung Cancer
Primary: Median Progression Free Survival (PFS) (Months) — 18.9; 10.2; 17.8; 9.8 Months — p=<0.0001
Tinnitus
Primary: Change in Tinnitus Functional Index (TFI) Score — -1.8; -2.5 score on a scale