4,901 trials
Breast Neoplasms
Primary: Number of Participants With Dose Limiting Toxicities (DLT) — 4; 2 Participants
MDS · AML · Solid Tumors
Primary: Area Under the Plasma Concentration-time Curve From Time 0 to 8 Hours Post-dose — 455.86; 897.43; 921.87; 1502.86 ng*hr/mL
Carcinoma · Non-Small-Cell Lung Carcinoma · Head and Neck Neoplasms
Primary: Change From Baseline in Standardised Uptake Value (SUVmax) as Measured by 2-[F-18]-Fluoro-2-deoxy-D-glucose Positron Emission Tomography (FDG-PET) — -18.386 Percentage…
Liver Diseases · Healthy
Primary: Area Under Curve From 0 to Infinity (AUC0-infinity) — 886; 552; 934; 956 ng*h/mL — p=0.1998
Neoplasms
Primary: Number of Participants With Dose Limiting Toxicities (DLT) in the First Cycle for the Determination of the Maximum Tolerated Dose (MTD) — 0; 0; 2; 2 Participants
Atherosclerosis · Aneurysm
Primary: Technical Feasibility- Successful Stent/Coil Placement (Post Procedure) — 100; 90 percentage of stable placement
Breast Cancer
Primary: Maximum Tolerated Dose (MTD) — 10 milligrams
Renal Insufficiency
Primary: Area Under the Concentration-time Curve From Time 0 to Infinity (AUC0-∞) — 305315.22; 435500.38; 658413.69 pg*hr/mL
Cancer
Primary: Mean (SD) Maximum Observed Concentration (Cmax) of Eribulin — 207; 106 ng*mL
Alzheimer's Disease
Primary: Whole Body Radiation Dosimetry — 0.0186; 0.0132; 0.0179; 0.0157 mSv/MBq
Primary Sclerosing Cholangitis
Primary: Change From Baseline in Alkaline Phosphatase Following 12 Weeks of Treatment — -117; -49; -62; -36 U/L
Rheumatoid Arthritis
Primary: Percent Change in Synovial Transfer Constant (Ktrans) From Days 1-29 — 15.04 Percent change
HIV Infections
Primary: Least Squares Mean Steady State Plasma Concentration (C12hrs) of Raltegravir After Coadministration of Antacid (Primary Hypothesis) — 132.30; 89.75; 49.38 nM
Influenza
Primary: Serum Haemagglutination-inhibition (HI) Antibody Titers, Against Each of the Vaccine Influenza Virus Strains. — 21.4; 22.2; 23.3; 18.4 Titer
Quadriplegia · Spinal Cord Injury · ALS
Primary: Fitts' Law: Horizontal Tapping Using TDS, Keypad, and Mouse (Throughput) — 1.97; 2.03; 1.54; 2.04 bits per second