Phase 1 N=18 A Study of Baricitinib and Ciclosporin in Healthy Participants
Healthy Volunteers
Primary: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Baricitinib — 36.2; 35.8 nanograms/milliliter (ng/mL)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=62 A Study of LY3009104 in Healthy Participants
Healthy Participants
Primary: Change From Baseline Through 24 Hours Postdose in Population-Corrected QT (QTcP) Interval — -2.5; -2.4; 9.7; -1.7 milliseconds (msec)
N/A N=70 Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED
Reproductive Tract Infections
Primary: Percentage of Participants Prescribed Antibiotic Treatment — 7.1; 5.7 percentage of 70 participants
Phase 1 N=18 A Study of Baricitinib and Rifampicin in Healthy Participants
Healthy Volunteers
Primary: PK: Maximum Concentration (Cmax) of Baricitinib — 96.1; 101 nanograms per milliliter (ng/mL)
Phase 1 N=36 A Study of Baricitinib When Administered With Ketoconazole or Fluconazole in Healthy Participants
Healthy Volunteers
Primary: Pharmacokinetics (PK): Area Under the Plasma Concentration-Time Curve From Time 0 Hour to Infinity [AUC(0-∞)] of Baricitinib Following Single Doses of Baricitinib Alone…
N/A N=120 China Adherence Through Technology Study
Medication Adherence
Primary: Difference in Proportion of Subjects Who Achieve >/= 95% Adherence — 55; 29 Participants
N/A N=30 Magnesium Sulfate vs Placebo for Placental Abruption
Abruptio Placentae
Primary: Undelivered With Resolution of Vaginal Bleeding and Contractions in First 48 Hours — 12; 10 participants — p=0.68
N/A N=49 Pilot Study of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
Cataract
Primary: Uncorrected Visual Acuity Across a Range of Distances at Month 6 — 0.05; 0.15; 0.09; 0.05 logMAR
Phase 2 N=90 Enhancing Breast Milk Production With Domperidone in Mothers of Preterm Neonates
Low Milk Supply
Primary: Increase in Breast Milk Production — 35; 26 Participants
N/A N=168 Motivational Interviews for Depression in Primary Care
Major Depression
Primary: Depression Remission — 4; 15 participants
Phase 3 N=72 Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer
Cancer · Fatigue
Primary: Fatigue as Measured by the Physical Fatigue Scale in the The Multidimensional Fatigue Inventory (MFI) (Smets EM, Garssen B, Bonke B, et al., J Psychosom Res 39:315-325…
N/A N=49 Temporal Artery Temperature Measurement in Neonates
Newborn Infant
Primary: Temporal Artery Temperature — 37.16 degrees Celsius
Phase 2 N=20 A Randomized, Double-Blind, Placebo-Controlled Study of Oral Milk Immunotherapy for Cow's Milk Allergy
Milk Hypersensitivity
Primary: The Median Milk Threshold Dose Inducing a Reaction — 40; 40; 5100; 0 miligrams
Phase 2 N=39 Rituximab in Treating Patients With Hodgkin's Lymphoma
Lymphoma · Hodgkin Lymphoma (Category) · Nodular Lymphocyte Predominant Hodgkin Lymphoma
Primary: Progression-free Survival (PFS) — 18 participants
Phase 4 N=12 Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease
Microvascular Angina
Primary: Seattle Angina Questionnaire Score — 83.3; 29.2; 74.1; 67.6 units on a scale