65,437 trials
Vascular Access Complication
Primary: First Attempt Success Rate — 92 Participants
Dengue
Primary: Systemic and Local Reactogenicity Rates for Ungraded Symptoms — 0; 1; 0; 2 Participants
Malignancy · Metastasis
Primary: Number of Participants With Adverse Events (AEs) — 3; 7; 6; 1 participants
Myopia
Primary: Visual Acuity — 80; 40 eye
Type 2 Diabetes
Primary: Change From Baseline in HbA1c at 52 W — -0.66; -0.77 percent — p=0.087
Type 2 Diabetes Mellitus
Primary: HbA1c at 6 Months — 8.65; 8.75; 8.37; 8.34 percentage of Glycated Haemoglobin — p=0.8222
Multiple Sclerosis
Primary: Change From Baseline in the Average Number of Time Constant 1 (T1) Contrast-enhanced Lesions (CELs) Over On-treatment Scans — 7.4; -2.4 lesions
Parkinson's Disease · Depression
Primary: Motor Subscale of the Unified Parkinson's Disease Rating Scale (UPDRS Part III) — 32.3; 33.1; 32.8; 28.9 units on a scale
Healthy
Primary: Area Under the Concentration-time Curve of Nintedanib in Plasma Over the Time Interval From 0 to the Last Quantifiable Concentration (AUC0-tz) — 195; 193 nanogram…
Surveillance
Primary: Number of Participants Reporting One or More Adverse Drug Reactions — 19; 1 participants
Secondary Hyperparathyroidism
Primary: Percent Change From Baseline in Mean Pre-hemodialysis Parathyroid Hormone (PTH) During the Efficacy Assessment Phase — 0.3; -19.4; 28.5; -49.4 percent change — p=<0.0001
Alzheimer's Disease
Primary: Change From Baseline in Activities of Daily Living (ADL) at 18 Months — -11.58; -13.45 units on a scale — p=0.82
Acute Lymphocytic Leukemia
Primary: Percentage of Participants Reporting Dose Limiting Toxicities (DLTs) During the Phase 1 Dose-Finding Phase — 0; 0; 11.1 Percentage of Participants
Cancer · Brain Cancer · Meningioma
Primary: Number of Participants Experiencing Serious Adverse Events Including But Not Limited to Hospitalizations, Deaths Related to Treatment, or Other Incapacitating…
Crohn's Disease
Primary: Percentage of Participants With Crohn's Disease Activity Index (CDAI) 70 Response Rate — 52.7; 60.1; 62.7; 47.7 Percentage of Participants — p=0.3393