12,372 trials
Arthritis, Rheumatoid
Primary: Percentage of Participants With an American College of Rheumatology 20% (ACR20) Response at Week 22 — 68.1; 59.1 percentage of participants
Erythropoietic Protoporphyria
Primary: Duration of Direct Sunlight Exposure Between 10:00 and 18:00 Hours on Days When no Pain Was Experienced (Pain Score of 0). — 69.4; 40.8 hours
Development
Primary: 17-hydroxyprogesterone Response to ACTH — 2.4; 3.7; 3.1; 2.9 ng/mL
Congenital Bleeding Disorder · Haemophilia A
Primary: Haemostatic Effect of Turoctocog Alfa (Treatment of Bleeds): 6 Months — 35; 156; 20; 190 Bleeding episodes
Non-small Cell Lung Cancer
Primary: Overall Survival (OS) in Participants With a Tumor Proportion Score (TPS) of ≥50% — 20.0; 14.0 Months
Varicella
Primary: Percentage of Participants With Varicella Zoster Virus Antibody Levels ≥5 Glycoprotein Enzyme-linked Immunosorbent Assay (gpELISA) Units/mL — 98.4; 98.3 Percentage of…
Hemophilia A
Primary: Percentage of Participants With a Total Annualized Bleeding Rate (ABR) of Zero for Second Six Months — 42.1; 62.1 Percentage of participants — p=0.0545
Acne Vulgaris
Primary: Investigator Global Assessment (IGA) Success Rate at Week 12 — 180; 116 Participants
Opioid Use Disorders
Primary: Response Rate, Denoted by Response Rate (Weeks 1-24). — 31; 37; 184; 176 Participants — p=<0.001
Pediatrics · Muscle Spasticity · Cerebral Palsy
Primary: Percentage of Participants With at Least One Treatment- Emergent Adverse Event (TEAE) — 58.7 percentage of participants
Depression · Sexual Dysfunction
Primary: Change in Massachusetts General Hospital Sexual Dysfunction Inventory Scores — .249; .017 score on a scale — p=.016
Major Depressive Disorder
Primary: Number of Participants With Treatment-emergent Adverse Events (TEAEs) in the Treatment Period — 274 Participants
Pediatrics · Muscle Spasticity · Cerebral Palsy
Primary: Percentage of Participants With at Least One Treatment-emergent Adverse Event (TEAE) — 65.4 percentage of participants
Delirium · Impaired Cognition · Long Term Psychologic Disorders
Primary: Delirium/Coma-free Days (DCFDs) — 8; 8; 7 days
Diabetes · Diabetes Mellitus, Type 2
Primary: Change in HbA1c — -1.6; -0.2 Percentage of HbA1c — p=<0.0001