Phase 2 N=219 Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis (Taski-3)
Rheumatoid Arthritis
Primary: American College of Rheumatology 20 (ACR20) Response at 3 Months — 27; 56 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=938 Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study
Osteoarthritis, Knee · Arthritis, Rheumatoid
Primary: Survivorship (Revision of Any Component for Any Reason) — 96.8; 98.1 percentage of knees
Phase 2 N=67 Influence of Ribavirin on the Initial Virological Response in Treatment Naïve Patients With Hepatitis C Genotype 1 Infection
Hepatitis C, Chronic
Primary: Log Likelihood Median Values of Hepatitis C-Virus (HCV) Kinetic Models for Quantitative HCV Ribonucleic Acid (RNA) Measurement With Various Assumptions of Ribavirin…
N/A N=3,339 Ramelteon Tablets 8mg Drug Use Surveillance: Survey on Insomnia Associated With Sleep-onset Difficulty
Insomnia
Primary: Number of Participants Reporting One or More Adverse Drug Reactions — 109 participants
Phase 4 N=25 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion
Concussion
Primary: Time (in Days) That a Patient Reports Symptoms From Their Concussion. — 7.3; 4.5 Days Symptomatic — p=.42
N/A N=22 A Trial of Radiofrequency Ablation for Anal Intraepithelial Neoplasia Using the HALO Ablation System
HIV-negative Subjects With Intra-anal Intraepithelial Neoplasia Containing High-Grade Squamous Intraepithelial Lesions
Primary: Clearance of Anal HSIL (High Grade Squamous Intraepithelial Lesion (HSIL) — 19 participants w histological clearance
Phase 4 N=205 Randomized Trial of High Dose Influenza Vaccine in Long Term Care Setting
Influenza
Primary: Non-inferiority of High-dose Inactivated Influenza Vaccine(HDIV) Versus Standard Dose Inactivated Influenza Vaccine(SDIV) Among Residents of Long Term Care(LTC) Settings…
Phase 4 N=20 Memantine and Comprehensive, Individualized Management of Alzheimer's Disease and Caregiver Training
Alzheimer's Disease
Primary: Change From Baseline in Clinician Interview-Based Assessment of Change Plus Caregiver Input (CIBIC-Plus) Global Score (New York Univeristy Version) — 2.3; 5.22 units on…
Phase 1 N=44 Study to Assess the Effect of AZD9291 on the Blood Levels of Rosuvastatin, in Patients With EGFRm+ Non-small Cell Lung Cancer
Non Small Cell Lung Cancer
Primary: Assessment of Maximum Plasma Concentration (Cmax) for Rosuvastatin After a Single Dose Alone and in Combination With AZD9291 — 13.96; 24.03 nanogram per millilitre (ng/mL)
Phase 4 N=56 Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis
Tinea Pedis · Tinea Cruris
Primary: Naftifine Hydrochloride Pharmacokinetics Variables, Single and Multiple Dose — 138262.2; 15890.1; 68634.2; 17213.9 h*pg/mL
N/A N=10 A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia
Anal Intraepithelial Neoplasia (AIN) · High-grade Squamous Intraepithelial Lesions (HSIL)
Primary: Related Adverse Events — 1; 1 number of participants
Phase 1 N=25 Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer
Neoplasms, · Metastatic Cancer, · Non-Small Cell Lung Cancer
Primary: Cmax of Selumetinib After Single Dose — 2534; 1073; 370.3; 897.1 ng/mL
Phase 4 N=214 CO2 Versus Air Insufflation for Single-balloon Enteroscopy
Intubation Depth
Primary: Intubation Depth — 323.8; 238.3 cm
N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Phase 2 N=85 A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome
Irritable Bowel Syndrome
Primary: Mean Pain Bowel Symptom Scale (BSS) Score Over Last 4 Weeks of Study (Weeks 9-12) — 25.3; 42.0 units on a scale — p=0.008