Phase 1 N=40 Estradiol/Norethindrone Acetate Tablets, 1/0.5 mg Under Fed Conditions
Healthy
Primary: Cmax of Norethindrone (Maximum Observed Concentration of Drug Substance in Plasma) — 6.54; 6.06 ng/mL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=32 Drospirenone/Ethinyl Estradiol (3 mg/0.02 mg) Tablets Under Fasting Conditions.
Healthy
Primary: Cmax of Drospirenone(Maximum Observed Concentration of Drug Substance in Plasma) — 67.69; 74.33 ng/mL
Phase 1 N=36 Pharmacokinetic and Safety of Dexlansoprazole in Adolescents With Gastroesophageal Reflux Disease
Gastroesophageal Reflux
Primary: Tmax: Time to Reach the Maximum Plasma Concentration (Cmax) Pharmacokinetic Parameter — 4.65; 3.31 hours — p=0.095
Phase 1 N=15 Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer
Advanced Solid Tumors · Neoplasms
Primary: Maximum Plasma Concentration (Cmax) — 338.23; 308.37 nanogram (ng)/millilter(mL)
Phase 1 N=132 The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers
Healthy Volunteers
Primary: The Comparison of BTDS to Placebo Transdermal System (TDS): the Average Difference From Baseline Using QT Corrected From Within-subject Data (QTci) on Day 13 — 4.20…
Phase 1 N=40 Study in Healthy Volunteers to Prove That Two Rotigotine Patches From Different Manufacturing Sites Deliver Equivalent Drug Amount to the Body
Healthy Volunteers
Primary: AUC(0-tz) of Unconjugated Rotigotine — 4.3899; 4.4255 (ng/ mL)*h
Phase 1 N=36 Valacyclovir 1000 mg Tablet Under Fed Conditions
Healthy
Primary: Cmax (Maximum Observed Concentration of Drug Substance in Plasma) - Valacyclovir — 385.35; 350.86 ng/mL
Phase 1 N=20 Losartan Potassium/Hydrochlorothiazide 100/25 mg Tablets in Healthy Subjects Under Fasting Conditions
Healthy
Primary: Cmax of Losartan(Maximum Observed Concentration of Drug Substance in Plasma) — 509.63; 538.11 ng/mL
Phase 1 N=80 Losartan Potassium/Hydrochlorothiazide 100/25 mg Tablets in Healthy Subjects Under Non-Fasting Conditions
Healthy
Primary: Cmax of Losartan(Maximum Observed Concentration of Drug Substance in Plasma) — 458.29; 409.324 ng/mL
Phase 1 N=38 Relative Bioavailability of Colcrys™ 0.6 mg Tablets in Healthy Young and Elderly Volunteers Under Fasted Conditions
Healthy
Primary: Maximum Plasma Concentration (Cmax) — 2.60; 2.56 ng/mL
Phase 1 N=40 Buprenorphine 8 mg Sublingual Tablets Under Fasting Conditions
Healthy
Primary: Cmax of Buprenorphine. — 4.40; 3.88 ng/mL
Phase 1 N=32 Tamsulosin Hydrochloride 0.4 mg Capsules Under Fed Conditions
Healthy
Primary: Cmax (Maximum Observed Concentration of Drug Substance in Plasma) — 8.8694; 9.0150 ng/mL
Phase 1 N=165 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Corneal Epithelial Defect · Diabetic Retinopathy · Penetrating Keratoplasty
Primary: Patients With Corneal Epithelial Healing Time Within 14 Days — 78; 73 participants
Phase 1 N=20 Short-term Clinical Feasibility of the Provox XtraHMEs for Pulmonary Rehabilitation After Total Laryngectomy
Total Laryngectomy
Primary: Patient Preference for Provox HME or Provox XtraHME — 12; 3; 5 Patients
Phase 1 N=12 A Bioequivalence Study of 3 Formulations of Ondansetron in Healthy Adults (0869-095)(COMPLETED)
Chemotherapy-Induced Nausea and Vomiting
Primary: Area Under the Plasma Concentration-Time Curve From Zero to Infinity (AUC) of Ondansetron — 644; 712; 649 nM*hr