Phase 1 N=6 Absorption, Metabolism and Excretion Study of [14C]PBT2 and Absolute Bioavailability of PBT2
Healthy Volunteers
Primary: Absolute Bioavailability of PBT2 (F%) — 15.936 percentage of absolute bioavailability
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=241 OTX-14-003: A Phase 3 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Ocular Inflammation and Pain After Cataract Surgery
Post-Surgical Ocular Pain · Post-Surgical Ocular Inflammation
Primary: Number of Participants With an Absence of Anterior Chamber Inflammation — 63; 25 participants
Phase 4 N=179 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
Dental Plaque · Gingivitis
Primary: Dental Plaque Scores — 3.33; 3.22; 3.34 units on a scale — p=0.04
Phase 2 N=105 A Phase 2 Study With MIP-1404 in Men With High-Risk PC Scheduled for RP and EPLND Compared to Histopathology
Prostate Cancer
Primary: Assess the Ability of 99mTc-MIP-1404 to Detect Prostate Cancer Within the Prostate Gland. — 94.2 % sensitivity
Phase 3 N=49 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia
Schizophrenia
Primary: Mean Change From Baseline to Week 16 in Positive and Negative Syndrome Scale (PANSS) Total Score — -10.2 Units on a scale — p=<0.0001
Phase 3 N=468 Brexpiprazole in Patients With Acute Schizophrenia
Schizophrenia
Primary: Change From Baseline to Week 6 in PANSS Total Score — -15.9; -20.0; -24.0 units on a scale — p=0.0560
N/A N=316 Ambulatory Versus Conventional Approach Diagnosing OSA
OSA
Primary: Change in Epworth Sleepiness Score (ESS) Before and After 3 Months of Continuous Positive Airway Pressure (CPAP) Treatment — -2.2; -3.5 units on a scale
N/A N=16 Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
Spinal Cord Injuries · Brown Sequard · Central Cord Syndrome
Primary: Minute Ventilation - Phase 2 — 22.0; 18.6; 22.0; 22.1 percentage of baseline — p=<0.001
Phase 2 N=76 Docetaxel With Bevacizumab as First-Line Therapy in Treating Women With Stage IV Breast Cancer
Breast Cancer
Primary: Antitumor Activity Based on Time to Tumor Progression (TTP). — 9.3 months
Phase 2 N=10 Efficacy and Safety Study of SyB L-0501 for Patients With Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
Primary: Response Rate [Complete Remission (CR) +Complete Remission / Incomplete (CRi) + Nodular Partial Remission (nPR) + Partial Remission (PR)] Based on International Workshop…
N/A N=532 Moxy Drug Coated Balloon vs. Standard Balloon Angioplasty for the Treatment of Femoropopliteal Arteries
Femoral Artery Stenosis · Popliteal Artery Stenosis · Femoral Artery Occlusion
Primary: Percentage of Participants With Composite Freedom From All-Cause Peri-Operative (≤30 Day) Death and Freedom From Index Limb Amputation, Index Limb Re-Intervention, and…
N/A N=26 Dehydration of Omafilcon A Contact Lenses Versus Delefilcon A Contact Lenses
Myopia
Primary: Absolute Change in Water Content (Mean) of Omafilcon A and Delefilcon A — 1.59; 3.82 absolute WC change
N/A N=14 Effect of Formoterol on the Counterregulatory Hormonal Response to Hypoglycemia in Type 1 Diabetes.
Type 1 Diabetes
Primary: Glucagon (pg/mL) — 76; 74; 53; 56 pg/mL
N/A N=30 PUFA Supplementation in Premature Infants
Premature, Extremely Low Birth Weight Infants · Polyunsaturated Fatty Acid Levels
Primary: Long-chain Polyunsaturated Fatty Acid (LCPUFA) Levels — 4.45; 4.02; 5.27; 20.3 weight % (g/100g)
Phase 2 N=112 A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas
Glioblastoma Multiforme · Gliosarcoma · Anaplastic Astrocytoma
Primary: Progression Free Survival at 6 Months — 1.71; 0.89; 8.7; 17.4 percentage of participants