65,437 trials
Major Depressive Disorder
Primary: Change in Resting State fMRI Connectivity of the Positive Valence System — 0.18; 0.18; 0.24; 0.29 rsFC correlation coefficient — p=0.6249
Type 2 Diabetes
Primary: Change From Baseline in Hemoglobin A1c (HbA1c) [Noninferiority] — -0.81; -0.72 Percentage of HbA1c
Presbyopia
Primary: Percent of Subjects With ≥ 15 Letters of Improvement in Photopic Binocular DCNVA and With < 5 Letters of Loss in Photopic Binocular BCDVA in Nyxol-treated Subjects — 27…
Pain Management
Primary: Narcotic Use — 8; 6.75 MME
Hypertension
Primary: Difference in Change in Home Seated Mean Systolic Blood Pressure (SBP) From Randomization to Week 4 — -9.6; -10.4; -2.2 mmHg — p=<0.0001
Preeclampsia
Primary: Microvascular Endothelial Function (Cutaneous Conductance, %Maximum) — 95; 77 % of maximal cutaneous conductance
Spinal Muscular Atrophy
Primary: Overview of Treatment-emergent Adverse Events by Age Subgroup — 27; 13; 4; 0 Participants
Obstructive Sleep Apnea · OSA
Primary: Test of Perception of Variations in the Passage of an Airflow Through the Rhino-oro-pharyngeal Passages According to the Categories of Items Used in the OSASSS…
Venous Leg Ulcer
Primary: Mean Relative Wound Area Reduction as Indication of Total Wound Healing — 46.3; 43.9 relative wound area reduction (%)
Arthritis Juvenile Idiopathic
Primary: Time to Systemic Juvenile Idiopathic Arthritis (sJIA) Disease Flare: Double-Blind Phase — NA; 295.0 Days — p== 0.1171
Hypertension
Primary: Difference in Change in Home Seated Mean Systolic Blood Pressure (SBP) From Randomization to Week 12 — -4.0; 1.4; -1.5; 0.4 mmHg — p=<.0001
Atypical Hyperplasia · Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia · Endometrial Carcinoma
Primary: Change in Tumor Proliferation — -0.17 percent (represented by mean) of cells
Brain Tumor · Low Grade Glioma · Astrocytoma
Primary: Endocrine Dysfunction — 14.5; 20.2 percentage of participants
Carpal Tunnel Syndrome · CTS
Primary: Boston Carpal Tunnel Questionnaire - Symptom Severity Scale (BCTQ-SSS) — -1.543 units on a scale
Primary Progressive Aphasia
Primary: Connectivity Measures of the Left TGd, 55b, and STV Parcellations at Baseline and Post-treatment — -.06; .03; -.01 correlation