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12,372 trials

Phase 3 N=156 A Phase 3 Study of Tezacaftor (VX-661) in Combination With Ivacaftor (VX-770) in Subjects Aged 12 Years and Older With Cystic Fibrosis (CF), Who Have One F508del-CFTR Mutation and a Second Mutation That Has Been Demonstrated to be Clinically Responsive to Ivacaftor

Cystic Fibrosis
Primary: Absolute Change From Baseline in Percent Predicted Forced Expiratory Volume in 1 Second (FEV1) Through Week 8 — 0.5; 0.2 Percent predicted of FEV1 — p== 0.5846
Vertex Pharmaceuticals Incorporated Results Jan 2019 4.2% serious AE View details