Phase 2 N=123 Erlotinib Versus Pemetrexed as Second-Line Therapy in Treating Patients With Advanced Lung Adenocarcinoma
Lung Cancer
Primary: Progression-Free Survival — 4.1; 3.9 months
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=47 Palifermin for the Reduction of Oral Mucositis in Single-dose Evaluation (PROMISE)
Cancer · Lymphoma · Leukemia
Primary: Number of Participants With Severe Oral Mucositis (WHO Grade 3 and 4) — 9; 6; 4; 9 participants
Phase 2 N=155 Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation
Graft Versus Host Disease · Hematologic Malignancies
Primary: Number of Participants With Severe (Grade 3 and 4) Acute Graft Versus Host Disease (GVHD) — 12; 12; 60; 62 Participants — p=0.929
N/A N=994 Evaluation of Treatment With Zemplar Capsules in the Therapy of Secondary Hyperparathyroidism (SHPT)
Chronic Kidney Disease · Secondary Hyperparathyroidism
Primary: Time to Achieve a > 30% Decrease From Baseline in Intact Parathyroid Hormone (iPTH) Values — 3.82 months
Phase 3 N=188 Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
Mucositis · Solid Tumors · Stomatitis
Primary: Number of Participants With Severe (Grade 3 or 4) Oral Mucositis — 62; 51; 29; 43 participants — p=0.0410
Phase 3 N=67 Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia
Schizophrenia · Schizoaffective Disorder · Agitation
Primary: The Change of the Positive and Negative Symptom Scale Excited Component (PANSS-EC) Score From Baseline to 120 Minutes After First Injection — -10.2; -9.9 units on a…
Phase 4 N=292 Efficacy and Safety of Sitagliptin/Metformin Fixed-Dose Combination (FDC) Compared to Glimepiride in Participants With Type 2 Diabetes Mellitus (MK-0431A-202)
Type 2 Diabetes Mellitus
Primary: Change From Baseline in Hemoglobin A1C (HbA1C) at Week 30 — -1.5; -0.7 Percent of total hemoglobin — p=<0.001
Early Phase 1 N=5 The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease · Chronic Bronchitis
Primary: Number of Coughs Following Capsaicin Inhalation Challenge at Baseline and Following 30 Days of Treatment With Spiriva (Baseline and 30 Days) — 2.5 coughs per dose of…
N/A N=57 Oxidized Omega-3 Supplements With Different Oxidation
Overweight
Primary: Weight (Kilogram) of Volunteers at the Beginning (Day 1) and at the End of the Study (Day 30) — 70.17; 68.77; 75.15; 69.38 kilogram
Phase 3 N=224 SMART Study: A Study of Re-treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on Anti-TNF Alfa Therapy
Rheumatoid Arthritis
Primary: Disease Activity Score Based on 28-Joints Count and C-Reactive Protein (DAS28-CRP) Area Under the Curve (AUC) at Week 104 — 2761.4; 2666.0 score on a scale*week
Phase 4 N=104 Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Myocardial Infarction · Reperfusion Injury
Primary: Cardiac Death — 0; 0 events
N/A N=147,494 A Study to Describe Pediatric Influenza Vaccine Coverage
Healthy
Primary: Influenza Vaccine Coverage in Participants <18 Years of Age by Age Group in Pediatric Practices — 46.5; 30.9; 30.6; 19.4 percentage of participants
Phase 4 N=87 Community Care for Croup (RCT)
Croup
Primary: Additional Health Care — 7; 2 percentage of participants — p=0.34
Phase 2 N=12 Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury
Spinal Cord Injury
Primary: Change in Motor and Sensory Scores of the ASIA Impairment Scale (AIS) — 1.0; 2.7; 2.4; -1.2 scores on AIS Scale
N/A N=31 Use of an Insulin Infusion Conversion Equation (IICE) to Control Blood Glucose in Hospitalized Patients
Glucose, Blood
Primary: Percentage of Blood Glucose Values Within 80-140 mg/dL — 54.8; 21.2 percentage of blood glucose values