Phase 4 N=28 Treximet in the Treatment of Chronic Migraine
Chronic Migraine
Primary: Percent Change of Migraine Headache Days Compared to Baseline — -8.06; -56.37 percent migraine headache days per month
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=82 Spinal Anesthesia Induced Hypotension During Cesarean Section
Hypotension
Primary: Incidence of Maternal Hypotension — 10.8; 27 percentage of participants
Phase 4 N=126 Prandial Insulin Dosing in Hospitalized Patients
Diabetes · Admitting Hospital · Non-critically Ill
Primary: Mean Glucose — 158; 171 mg/dl
Phase 4 N=7 Drug Interaction Study Between Linezolid and Clarithromycin in Tuberculosis Patients
Multidrug-resistant Tuberculosis · Extensively Drug-resistant Tuberculosis
Primary: Area Under the Time Concentration Curve (AUC0-12h) of Linezolid in Plasma After Addition of 0mg, 250mg, or 500mg Clarithromycin (CLA). — 36.3; 61.0; 67.2 mg*h/L
Phase 4 N=283 Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder
Bipolar Disorder
Primary: Overall Change in Bipolar Illness Severity as Measured by Clinical Global Impression for Bipolar Disorder Severity (CGI-BP-S) Score — -1.22; -1.48 units on a scale…
Phase 4 N=371 Comparison of Three Hepatitis B Vaccination Regimens in HIV-Positive Youth
HIV Infection · Hepatitis B
Primary: Sero-response to Hepatitis B Surface Antigen — 60; 73.2; 75.4 percentage of participants who resonded — p=0.0440
Phase 4 N=72 Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT)
Myelodysplastic Syndromes · Myeloproliferative Disorders · Leukemia, Lymphocytic
Primary: Non-relapse Mortality — 3; 4; 2 participants — p=.07
Phase 4 N=308 Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression
Major Depressive Disorder
Primary: CDRS-R Total Score (Child) (mITT w/LOCF Population) Week 12 — 57.9; 56.7; 36.4; 35.4 units on a scale
Phase 4 N=551 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Hepatitis Be Antigen (HBeAg) Positive Chronic Hepatitis B (CHB).
Hepatitis B, Chronic
Primary: Percentage of Participants With Hepatitis Be Antigen (HBeAg) Seroconversion 24 Weeks Following End of Treatment — 14.08; 22.86; 25.76; 36.15 Percentage of participants
Phase 4 N=140 A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
Osteoarthritis
Primary: Change From Day 29 in Western Ontario and McMaster Universities Arthritis Index (WOMAC) Total Score at Day 85 — 33.54; 39.44; -1.88; -0.07 units on a scale — p=0.4258
Phase 4 N=33 The Effect of a Peroxisome Proliferator-activated Receptor (PPAR) Alpha Agonist on Cytochrome P450 (CYP) Monooxygenase Activity in Humans
Hypertension
Primary: Change in Blood Pressure During High Salt Intake and Fenofibrate Treatment Compared to High Salt Intake and Placebo Treatment — 2.0; -3.4 mm Hg
Phase 4 N=57 Rasagiline in the Treatment of Persistent Negative Symptoms of Schizophrenia
Schizophrenia
Primary: Change in Negative Symptoms — 32.7; 33.5; 31.2; 32.3 units on a scale
Phase 4 N=245 Open Label Comparative Study Of De Novo Renal Allograft Recipients Receiving CSA + MMF + Corticosteroids Versus CSA + Rapamune + Corticosteroids
Inflammation
Primary: Incidence of Efficacy Failure — 11.4; 13.5 percentage of participants — p=0.341
Phase 4 N=201 An Efficacy and Safety Study Comparing Oral Contraceptive Containing Norgestimate or Desogestrel for Acne Treatment
Acne Vulgaris
Primary: Change From Baseline in Total and Each Type of Acne Lesions Count at Month 1 — 10.97; 11.43; 4.32; 4.46 Lesions
Phase 4 N=30 Open-Label Study of Geodon in Non-Rapid Cycling Bipolar II Patients With Major Depression
Bipolar II Disorder · Major Depressive Episode
Primary: The Primary Efficacy Endpoint is the Comparison of Baseline and Week 8 Endpoint in the 17-item HAM-D Total Scores — 23.1; 10.57 Scores on a scale — p=<0.0001