Phase 4 N=31 Memantine Augmentation of Antidepressants
Depressive Disorder
Primary: Montgomery-Asberg Depression Rating Score (MADRS) — -7.25; -7.13 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=59 Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy
Narcolepsy
Primary: Adverse Experiences — 54 participants
N/A N=19 Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
Bipolar Depression
Primary: Mean Concentrations of Cerebral Energetic Metabolites in Geriatric BPD and Older Controls at Baseline — 4.35; 3.94; 3.23; 3.06 Integration Expressed as Arbitrary Unit
Phase 3 N=286 Targeting Inflammation Using Salsalate for Type 2 Diabetes-Stage II
Type 2 Diabetes Mellitus
Primary: The Primary Outcome for the TINSAL-T2D Study is Change in HbA1c Level From Baseline to Week 48 From Baseline, Compared Between Treatment Groups. — -0.04; -0.33 HbA1c…
Phase 4 N=245 Comparison of Two Biphasic Insulin Aspart 30 Treatment Regimens in Subjects With Type 2 Diabetes Not Achieving HbA1c Treatment Targets on OADs Alone
Diabetes · Diabetes Mellitus, Type 2
Primary: Change in Glycosylated Haemoglobin (HbA1c) From Baseline to Week 11 — -1.04; -0.90 percentage of glycosylated haemoglobin — p=<0.001
Phase 3 N=735 Safety and Tolerability of a Single Dose of FCM vs. Standard of Care in Treating Iron Deficiency Anemia
Anemia
Primary: Number of Participants With Treatment-emergent Serious Adverse Events (SAE's) — 5; 9 participants
Phase 2 N=36 Bevacizumab and Erlotinib in Treating Patients With Metastatic Pancreatic Cancer That Did Not Respond to Previous Treatment With Gemcitabine
Pancreatic Cancer
Primary: Overall Survival Rate at 6 Months — 8 participants
Phase 2 N=137 Bevacizumab or Cetuximab And Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Pacreatic Cancer That Has Been Completely Removed By Surgery
Stage IA Pancreatic Cancer · Stage IB Pancreatic Cancer · Stage IIA Pancreatic Cancer
Primary: Proportion of Patients With Specific Protocol Defined Adverse Event at Conclusion of All Therapy — 0.30; 0.25 Proportion of patients
Phase 4 N=102 Electrophysiologically Guided PAcing Site Selection Study
Sinus Arrhythmia · Atrial Fibrillation
Primary: Number of Patients With Persistent Atrial Fibrillation (AF) After a Mean Follow-up of 15±7 Months: Comparison Between IAS and RAA Pacing in the Study Group — 2; 2; 9; 2…
Phase 3 N=28 Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients
Hemophilia B
Primary: Study Part 1- Area Under the Plasma Concentration Versus Time Curve From 0 to 72 Hours Per Dose — 14.30; 13.42 (IU·hr/dL) / (IU/kg)
N/A N=483 Perioperative Management of Patients With Coronary Stents Undergoing Noncardiac Surgery
Acute Coronary Syndrome · Coronary Stent Occlusion · Surgery
Primary: Major Adverse Cardiac and Cerebrovascular Events (MACCEs) — 63 participants
Phase 3 N=250 VIT45 Versus Oral Iron in the Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease
Anemia
Primary: Number of Subjects Achieving an Increase in Hemoglobin ≥1g/dL — 87; 35 participants
Phase 3 N=13 A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in the Central Nervous System in HIV-1 Infected ART-naive Subjects
Infection, Human Immunodeficiency Virus
Primary: The Ratio of Total and Unbound DTG Concentrations Between Cerebrospinal Fluid (CSF) and Plasma at Week 2 and Week 16 — 0.516; 0.412 percentage
Phase 2 N=36 Weekly Dosing of Malarone ® for Prevention of Malaria
Malaria
Primary: Prophylactic Efficacy of 3 Different Doses of Atovaquone/Proguanil (Malarone@) Given 1 Week Before Infectious Sporozoite Challenge Using the P. Falciparum Human…
Phase 2 N=46 S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors
Lung Cancer
Primary: Feasibility of Treating Patients With Stage IIB/IIIB Pancoast Tumors With a Regimen of Cisplatin and Etoposide Plus Concurrent Radiotherapy Followed by Surgical…