65,437 trials
Healthy Volunteers
Primary: Maximum Observed Concentration (Cmax) of Ritlecitinib: MR Capsules vs Oral Solution Under Fasted Condition — 671.6; 145.1; 84.96 Nanogram per milliliter (ng/mL)
Severe Haemophilia A
Primary: Number of Participants With Treatment Emergent Adverse Events — 1; 1; 6; 7 Participants
Coronary Artery Disease
Primary: Correlation in MBF Between Core Laboratory and Local Site — 0.93 correlation coefficient
Multiple Myeloma
Primary: Part 1: Number of Participants With Dose Limiting Toxicities (DLTs) — 0; 0 Participants
Nicotine · Nicotine Vaping · E-cigarette Use
Primary: Behavioral Intentions for Continued Use — 3.73; 3.88; 3.91; 3.74 score on a scale
Alopecia Areata · Alopecia · Alopecia Totalis
Primary: Number of Treatment Emergent Adverse Events — 27 Participants
Alcohol Use Disorder
Primary: Reinforcing Effects (Pre-Alcohol Dose Consumption) — 0.005; .01; 0.007; 0.005 Units on a Theoretical Scale
Carcinoid Syndrome · Metastatic Nonfunctional Well Differentiated Neuroendocrine Neoplasm
Primary: The Proportion of Patients Who Achieved SUVmax Reduction of 20% or More Between Baseline and Follow up Scan — 0 Proportion of participants
Knee Osteoarthritis
Primary: Penetration — 1.41; 1.13 patients per month — p=0.92
Healthy Study Participants
Primary: Area Under the Plasma Concentration-time Curve From Time Zero to Infinity (AUC) for a Single Dose Bimekizumab (BKZ) — 1223; 1255 days*micrograms/milliliter (days*ug/mL)
Hearing Disability
Primary: Ease of Understanding Another Person — 0; 24; 4; 67 Participants
Hearing Loss
Primary: Change in Hearing Aid Benefit as Measured by Abbreviated Profile of Hearing Aid Benefit (APHAB) — -19.74; -14.41 score on a scale — p=0.003
Dementia, Alzheimer Type · Weight Loss
Primary: Monthly Weight in Pounds on a Scale for Person With Dementia — -2.1; -2.1 pounds
Atrial Fibrillation, Persistent · Atrial Fibrillation · Arrhythmias, Cardiac
Primary: Number of Participants With Acute Procedure Success — 13 Participants
HIV Infections
Primary: Model Adjusted Probability of Any HIV Testing — 57.0; 91.0; 89.4 percent probability