12,372 trials
Diabetes · Diabetes Mellitus, Type 2
Primary: Change From Baseline in HbA1c (%) (Analysed by Central Laboratory) — -1.3; -1.2 percentage of glycosylated haemoglobin
Parkinson's Disease
Primary: Percentage of "Off" Time During Waking Hours at End of Study — 23.82; 29.79 percentage — p=<.0001
Moderate or Severe Submental Fullness
Primary: Number of Participants With Adverse Events (AEs) — 160; 7; 11; 15 participants
Melanoma
Primary: Progression-free Survival (PFS) According to Response Evaluation Criteria In Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Independent Radiology Plus Oncology…
Post Herpetic Neuralgia
Primary: Number of Participants With Loss of Therapeutic Response. — 29; 63 Participants — p=<0.0001
Polycystic Ovarian Syndrome (PCOS) · Irregular Menstrual Cycles · Androgen Excess
Primary: Total Serum Testosterone — 61.8; 41.6 ng/dL
Diabetes · Diabetes Mellitus, Type 1
Primary: Change From Baseline in HbA1c (Glycosylated Haemoglobin) (%) at 26 Weeks (Analysed by Central Laboratory) — -0.20; -0.31 percentage of glycosylated haemoglobin
Bipolar Depression
Primary: Mean Montgomery-Åsberg Depression Rating Scale (MADRS) Score at Baseline for Both Groups, and After 12 Weeks of Lamotrigine Monotherapy for the Bipolar Group — 27.79…
Overactive Bladder · Urinary Incontinence
Primary: Change From Study Baseline in Number of Episodes of Urinary Incontinence in Treatment Cycle 1 — 4.86; 5.23; 4.38; -3.10 Incontinence Episodes
Aspergillosis · Invasive Fungal Infections
Primary: Crude Success Rate of Overall Outcome of Treatment Evaluated by the Data Review Committee (DRC) at Day 42, 84 and End of Treatment (EOT). — 25.0; 50.0; 14.3; 9.1…
Seizure Disorder Generalized Tonic Clonic
Primary: Median Percent Change in Primary Generalized Tonic Clonic Seizure Frequency (PGTC) Per 28 Days During the Titration and Maintenance Periods (Combined) Relative to…
Vitreomacular Adhesion Including Macular Hole
Primary: Proportion of Subjects With Pharmacological Vitreomacular Adhesion (VMA) / (Vitreomacular Traction [VMT]) Resolution at Day 28 — 41.7; 6.2 Percentage (weighted across…
Opioid-Related Disorders · Heroin Dependence
Primary: The Primary Outcome Will Include a Comparison of the Proportion of Patients Successfully Inducted One Week After the Initial Primary Care Visit. — 6; 6 participants
HIV · HIV Infections
Primary: Percentage of Participants With HIV-1 RNA < 50 Copies/mL at Week 48 — 93.1; 92.8 percentage of participants — p=0.78
Schizophrenia
Primary: Change From Baseline in Positive and Negative Syndrome Scale (PANSS) Total Score at Week 6 for Lurasidone 20 mg and 80-160 mg Versus Placebo. — -17.6; -24.9; -14.5 units…