12,372 trials
Type 2 Diabetes Mellitus
Primary: Change From Baseline in Glycosylated Hemoglobin A1c (HbA1c) at 24 Weeks — -1.38; -0.11 percent change of HbA1c — p=<0.001
Major Depressive Disorder
Primary: Percentage of Subjects With Treatment Emergent Adverse Events (TEAEs) — 66.7 percentage of subjects
Relapsed or Refractory Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
Primary: PFS (Progression Free Survival) by Independent Review Committee (IRC), Limited to the Time of Primary Analysis 06 November 2013 — 8.1; NA months — p=<0.0001
Allergic Rhinitis
Primary: Change From Baseline in the Average Morning (AM) and Evening (PM) Subject-Reported Reflective Total Nasal Symptom Score (rTNSS) Over The First 6 Weeks Of Treatment In…
Breast Cancer
Primary: Disease Free Survival — NA; NA Months — p=0.3150
Major Depressive Disorder With Mixed Features
Primary: Mean Change From Baseline to the 6-week Study Endpoint in Montgomery-Asberg Depression Rating Scale (MADRS) Total Scores — -20.5; -13.0 units on a scale — p=<0.0001
Primary Hypercholesterolemia · Mixed Dyslipidemia
Primary: Percentage of Participants With Full Administration of Evolocumab at Both Weeks 2 and 4 — 96.0; 89.2 percentage of participants
Major Depressive Disorder (MDD)
Primary: Mean Change From Baseline to Week 6 in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -12.8; -18.4; -19.5; -19.2 Units on a scale — p=<0.0001
Allergic Rhinitis
Primary: Change From Baseline (Expressed As A Ratio) In 24-Hr Serum Cortisol Weighted Mean Following 6 Weeks Of Treatment — 1.04; 1.10 ratio
Asthma
Primary: Change From Baseline in Trough Morning Forced Expiratory Volume in 1 Second (FEV1) at Day 85 — 0.231; 0.203 Liter
Tetanus · Diphtheria · Pertussis
Primary: Percentage of Participants With Diphtheria and Tetanus Post-vaccination Booster Response Following Vaccination With Either SP306 or DT — 99.7; 98.3; 100; 93.8 Percentage…
Conjunctivitis, Allergic
Primary: Change From Baseline In Ocular Itching Frequency Score Using a 6-point Scale — 4.4; -3.4 Scores on a Scale
Bilateral LASIK Surgery
Primary: Ocular Surface Disease Index© (OSDI) Score Using a 5-Point Scale — 6.99; 6.63 Scores on a Scale
Juvenile Idiopathic Arthritis
Primary: Number of Participants With Adverse Events of Special Interest and Study-Drug Related Adverse Events — 6; 0; 1; 1 participants
Homozygous Familial Hypercholesterolemia
Primary: Part A: Percent Change From Baseline in Low Density Lipoprotein Cholesterol (LDL-C) at Week 12 — -16.5 percent change