12,372 trials
Major Depressive Disorder
Primary: Change From Baseline in 17-item Hamilton Raing Scale for Depression (HAM-D17) Total Score at Week 8 or Early Termination — -9.25; -10.76; -10.37 Units on a scale — p=0.031
Type 1 Diabetes
Primary: Change in Mean Weekly Glucose Concentrations — 1; -10; -10; -0.3 mg/dl
Pneumococcal Vaccines
Primary: Percentage of Participants Achieving a Serotype-Specific Pneumococcal Immunoglobulin G (IgG) Antibody Concentration Greater Than or Equal To (>=) 0.35 Microgram Per…
Coronary Atherosclerosis · Coronary Artery Calcification · Coronary Stenosis
Primary: Rate of Change in Total Coronary Calcium Scores by Computed Tomography — 32; 58 Agatston score change
Alopecia
Primary: Number of Participants With Any Adverse Events (AEs) and Any Serious Adverse Events (SAEs) — 64; 2 Participants
Idiopathic Pulmonary Fibrosis
Primary: Change in Percent Predicted Forced Vital Capacity (%FVC) From Baseline to Week 52 — 16.5; 31.8; 22.7; 9.7 percentage of patients
Glaucoma
Primary: Intraocular Pressure (IOP) — 11.52; 12.83 mmHg (millimeters of mercury)
Schizophrenia · Bipolar Disorder
Primary: Number of Subjects With Treatment Emergent AEs, SAEs or Who Discontinued Due to AEs — 63; 7; 10 participants
Osteoarthritis
Primary: Change From Baseline to Week 12 After Trial Entry in Osteoarthritis Pain Measured on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain…
Breast Cancer · Hot Flashes
Primary: Numerical Change From Baseline in Hot Flash Score at Treatment Week 6 (Positive Numbers to Represent Increases and Negative Numbers to Represent Decreases). — -9.6; -6.1…
Meningitis, Meningococcal
Primary: Percentage of Participants With at Least One Serious Adverse Event (SAE) Throughout the Study — 1.55; 2.52 percentage of participants
Keratoconjunctivitis Sicca
Primary: Number of Subjects Who Achieved Complete Clearing of Corneal Staining (i.e., Total Corneal FS Score = 0) at Week 24 — 15; 13; 21; 61 participants
Chronic Obstructive Pulmonary Disease
Primary: Change From Baseline in Standardized Area Under the Curve for Forced Expiratory Volume in One Second Post Dosing — 0.115; -0.008 Liters
Nausea · Vomiting
Primary: Change From Baseline of Peak Acute Nausea — 0.03; -0.56; -0.44; -0.15 units on a scale — p=.017
Multiple Myeloma
Primary: Maximum Severity of Oral Mucositis (World Health Organization (WHO) Grades 0/1, 2, 3, or 4) — 79; 36; 68; 26 Participants — p=0.188