Phase 1 N=30 Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup
Bronchitis
Primary: Carbocysteine Plasma PK Parameters: Cmax — 7.15; 6.34 µg/mL — p=0.0482
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=16 Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.
Addiction Opiate
Primary: Number of Participants With Dose Limiting Toxicities — 0; 0; 0; 0 participants
N/A N=89 Pediatric Cardiac Output Monitoring Observational Study
Pediatric ALL
Primary: Bias of FloTrac Arterial Pressure Cardiac Output (L/Min) Against Swan Ganz Invasive Cardiac Output — 0.49 L/min
Phase 1 N=114 MSB0011359C (M7824) in Participants With Metastatic or Locally Advanced Solid Tumors
Solid Tumors
Primary: Number of Participants With Dose Limiting Toxicity (DLT) — 0; 0; 1 Participants
Phase 2 N=51 Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Becker Muscular Dystrophy
Becker Muscular Dystrophy
Primary: Mean Change From Baseline to Visit 11 in Total Fibrosis (%) on Log Scale, Comparing the Histology of Muscle Biopsies — -0.017; -0.054 log[percentage of total fibrosis]…
Phase 2 N=64 Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
Alcohol Abuse · Alcohol Use Disorder · Alcohol Abuse, Episodic
Primary: The Young Adult Alcohol Consequences Questionnaire — -4.48; -4.63 outcome score minus baseline score
N/A N=600 Skin Health Online for Melanoma: Better Risk Assessment
Melanoma (Skin)
Primary: Reach of Personalized Genomic Testing for Melanoma. — 0; 204; 0; 295 Participants
N/A N=155 Comprehensive Geriatric Assessment for Frail Older People
Dependency
Primary: Dependence in Activities of Daily Living — 78; 77 Participants
N/A N=17 TRE With Physical Activity for Weight Management
Pre Diabetes · Overweight and Obesity
Primary: Body Weight Changes Between Week 1 to Week 10 — -2.1; -4.2; -1.3; .1 Percent body weight loss
N/A N=88 Blood Sampling Functionality of Extended Dwell Catheters
IV Catheter-Related Infection or Complication · Vascular Access Complication · Peripheral Venous Access
Primary: Blood Sampling Functionality — 70.19; 112.9 hours
N/A N=178 Evaluation of 3T, a Sex-Positive HIV/STI Mobile App Intervention for Young Black Men Ages 14-19 Attracted to Men
HIV/AIDS and Infections · Sexual Behavior · Health Knowledge, Attitudes, Practice
Primary: Condomless Anal Intercourse or Condomless Vaginal Intercourse — 49; 50 Participants — p=0.94
Phase 1 N=45 A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
Opioid Use Disorder
Primary: Number of Participants With Increased End-tidal Carbon Dioxide (EtCO2) of at Least 10 mmHg Compared to Baseline or > 50 mmHg on Day 1 — 0; 0 Participants
N/A N=48 REVITALIZE: A Telehealth Intervention for Women With Advanced Ovarian Cancer and PARP Inhibitor-Related Fatigue
Ovarian Cancer · Fatigue · Coping Behavior
Primary: Fatigue Interference — 3.76; 3.52; 2.80; 2.56 score on a scale (describing the units)
N/A N=26 Interaction Between Cannabidiol, Meal Ingestion, and Liver Function
Metabolism · Liver Function · Pharmacokinetics
Primary: Pharmacokinetic Time to Maximum Concentration- (Tmax) for Different Formulations of CBD — 116.3; 35.4; 51.8; 129.5 minutes
N/A N=46 Breath Analysis Based Disease Biomarkers
Liver Diseases · Liver Cancer · COVID19
Primary: Breath Volatile Organic Compound Profiles — 11; 35 Participants