12,372 trials
Diarrhea · Clostridium Infections
Primary: The Incidence of Antibiotic-associated Diarrhea. — 216; 221 participants
Rheumatoid Arthritis
Primary: Percentage of Participants With Adverse Events (AEs): Overall Summary — 77.4; 58.4; 7.8; 7.8 percentage of participants
Insomnia
Primary: Average Wake Time After Sleep Onset (WASO) During the In-Treatment Period — 45.6; 45.5; 76.1 Minutes
Hereditary Angioedema
Primary: Time to Onset of Symptom Relief for an Acute Attack, as Assessed by the Patient — 2.0; 19.8 Hours — p=<0.001
Depression · Major Depressive Disorder · Unipolar Depression
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) — 22.0; 18.0; 12.0; 14.0 units on a scale — p=.04
Necrotising Enterocolitis
Primary: Interleukin 5 Serum Cytokine Level on 0+2 Day — 4; 4 pg/ml — p=0.32
Chronic Myeloproliferative Disorders · Fatigue · Leukemia
Primary: Change From Baseline to Week 4 in the General Subscale of the MFSI-SF — 14.4; 8.2 units on a scale — p=0.0737
Rheumatoid Arthritis
Primary: Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) — 65.0; 68.6; 73.2; 8.5 percentage of participants
Schizophrenia, Paranoid · Schizophrenia, Disorganized · Schizophrenia, Undifferentiated
Primary: Number of Participants With a Treatment-Emergent Adverse Event (AE) During Extension Study — 114; 3 participants
Diabetic Foot Ulcer of Neuropathic Origin
Primary: Wound Closure Rate of Diabetic Foot Ulcers (DFUs) of Neuropathic Topical Daily Application of Trafermin 0.01% Spray Compared With Placebo, in Addition — 14.1; 10.8…
Acne Vulgaris
Primary: Absolute Change in Total Lesion Counts From Baseline to Week 12 — -42.9; -22.0 Lesion counts — p=<0.001
Insomnia · Sleep Initiation and Maintenance Disorders · Mental Disorders
Primary: Average Wake Time After Sleep Onset Measured by Polysomnography — 80.3; 79.6; 74.8; 109.8 Minutes — p=<0.0001
Diabetic Foot Ulcer of Neuropathic Origin
Primary: Wound Closure Rate of Diabetic Foot Ulcers (DFUs) of Neuropathic Origin After a Maximum of 12 Weeks Topical Daily Application of Trafermin 0.01% Spray Compared With…
Major Depressive Disorder
Primary: Change From Baseline to Week 8 in DSST (Number of Correct Symbols) and RAVLT (Acquisition and Delayed Recall) Using the Composite Z-score Defined as the Weighted Sum of…
Rheumatoid Arthritis
Primary: Percentage of Participants With Adverse Events During the Initial Treatment Period - Overall Summary — 85.0; 41.7; 20.8; 4.2 percentage of participants