4,901 trials
Healthy
Primary: Area Under the Concentration-time Curve of Midazolam in Plasma Over the Time Interval From 0 to the Last Quantifiable Data Point (AUC0-tz) — 19.0; 23.5; 16.0 nanogram…
Marijuana Use · Opioid Use
Primary: Self-Administration of Drug Units Earned — 0.00; 3.83; 3.67; 0.00 Number of drug units
Norovirus Infections
Primary: Number of Participants (Mothers) With Any Solicited Symptoms of Reactogenicity for 1 Week Following Trial Dose — 15; 8; 5; 1 Participants
Asthma
Primary: Area Under the Percent Radiolabeled Particle Retention-time Curve up to 4 Hours [AUC(0-4h)] After Nebulized 99mTechnetium (99mTc) Inhalation on Day 7 — 351.57; 351.76…
Parkinson's Disease
Primary: MRI-derived Free Water (FW) Levels — 7.9; -3.8; 1.5 % change
Non-Small Cell Lung Cancer · Malignant Melanoma · Head and Neck Squamous Cell Carcinoma
Primary: Maximum Tolerated Dose (MTD) — 20 mg/kg
Kidney Transplant Recipient
Primary: Number of Participants Who Are Compliant With Self-administration — 8; 5; 1 Participants
HIV · Prophylaxis · Transgender
Primary: Change in Maximum Tenofovir Plasma (Cmax) Concentration — 286; 276; 274; 277 ng/mL
Cerebral Palsy
Primary: Changes in pVO2 — 1.72; -0.61 mL/kg-1/min-1
Healthy Volunteers
Primary: Pharmacokinetics: AUC0-tau — 94.927; 107.30; 294.48; 1059.5 h*ng/mL
Healthy
Primary: Area Under the Concentration-time Curve of Midazolam in Plasma Over the Time Interval From 0 to the Last Quantifiable Data Point (AUC0-tz) — 70; 63 hours*nanomole/Liter…
Renal Insufficiency
Primary: Area Under the Concentration-time Curve of Iclepertin in Plasma Over the Time Interval From 0 to the Last Quantifiable Data Point (AUC0-tz) — 5014.15; 4702.56; 5099.51…
Healthy
Primary: Area Under the Concentration-time Curve of BI 425809 in Plasma at Steady State Over a Uniform Dosing Interval τ (AUCτ,ss) — 4063.86; 1957.60 hours * nanomole/liter…
Treatment Resistant Depression
Primary: Decrease in Depressive Symptoms — 12.13 Score on MADRS — p=0.0065
Healthy
Primary: Area Under the Concentration-time Curve of BI 425809 in Plasma Over the Time Interval From 0 to 72 Hours (AUC0-72) — 7904.16; 6400.59; 7648.23 nanomol (nmol) * hour (h)…