17,261 trials
Non-Small Cell Lung Cancer
Primary: Primary Pharmacokinetics (PK) Parameters of of LDK378 After Daily Oral Dose: AUClast, AUC0-24h, AUCinf — 10100; 3940; 11100 ng*hr/mL
Leukemia, Lymphocytic, Chronic, B-Cell
Primary: Percentage of Participants With CR Achieved After the Rituximab, Fludarabine, and Cyclophosphamide Regimen — 95.2 Percentage of Participants
Head and Neck Neoplasms · Mucositis
Primary: Incidence of Severe OM During Radiation Therapy in Subjects Receiving a Cumulative IMRT Dose of at Least 55 Gy — 15; 9; 10; 12 Participants
Influenza
Primary: Titers for Serum Hemagglutination Inhibition (HI) Antibodies Against A/California/7/2009 (H1N1)V-like Antigen — 8.8 Titers
Psoriasis Vulgaris
Primary: Number of Subjects With Adverse Events (AEs) — 8; 4; 1; 1 Participants
Asthma
Primary: Proportion of Patients With a Severe Asthma Exacerbation During 14 Days of Treatment — 7; 5 Participants — p=0.645
Multiple Myeloma
Primary: Response Conversion Rate — 8 Participants
Cocaine Dependence
Primary: Number of Participants That Achieved Study Compliance — 22; 15; 18 Participants
Spasticity
Primary: Least Square Mean Difference (Placebo Versus Each SPARC1103 Dose) in Change From Baseline in Modified Ashworth Score — 0.33; 0.03 score on a scale
Lysosomal Acid Lipase Deficiency
Primary: Participants Experiencing Severe Treatment-emergent Adverse Events (TEAEs) — 1; 1; 2 Participants
Hepatic Steatosis
Primary: Hepatic Triglyceride (%) — 15.9; 14.8 Fat/Fat+Water (%) — p=0.42
Adult Acute Erythroid Leukemia (M6) · Adult Acute Megakaryoblastic Leukemia (M7) · Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Primary: Response Rate (RR) — 3 Participants
Lung Cancer
Primary: Overall Survival and Progression Free Survival — 85.70; 60; 42.90; 28.10 percentage of participants (%)
AV Fistula
Primary: Time to AV Fistula Functional Maturation — 169; 145 Days to functional maturation
Traumatic Brain Injury
Primary: Dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6 Months — 107; 108; 110; 218 Participants — p=.1809