12,372 trials
Varicose Veins
Primary: Change in Patient-reported Symptoms of Varicose Veins (VVSymQ Score) — 2.13; 4.63; 5.68; 4.87 units on a scale — p==0.0001
Neurogenic Orthostatic Hypotension · Non-Diabetic Autonomic Neuropathy · Multiple System Atrophy
Primary: Change in Orthostatic Hypotension Questionnaire Composite Score (OHQ) — 0.57; 0.90 units on a scale — p=0.438
Diabetes Mellitus, Type 2
Primary: Change From Baseline in Glycosylated Hemoglobin (HbA1c) at Week 26 — -0.83; -0.52 Percentage of HbA1c in the blood — p=<0.0001
Diabetes Mellitus, Type 2
Primary: Change From Baseline (BL) in Glycosylated Hemoglobin (HbA1c) at Week 104 — 0.27; -0.28; -0.36; -0.63 Percentage of HbA1c in the blood — p=<0.0001
Cancer
Primary: Progression-free Survival (PFS) as Assessed by the Investigator — 6.9; 2.7 Months — p=<0.0001
Symptomatic Neurogenic Orthostatic Hypotension (NOH) · Non-diabetic Neuropathy · Primary Autonomic Failure
Primary: Change in Orthostatic Hypotension Questionnaire Score (OHQ) — -1.83; -0.93 units on a scale — p=0.003
Seasonal Allergic Rhinitis
Primary: Change From Baseline in Average Daily Subject Reported AM and PM Reflective Total Nasal Symptom Scores (rTNSS) Over the 2-week Double-blind Treatment Period — -1.63…
Acute Low Back Pain
Primary: Pain Intensity Difference (PID) Between Pre-dose Baseline and 8hours After First Application — -1.049; -1.428; -2.252; -2.410 units on a scale — p=<0.0001
Bowel Preparation Prior to Endoscopic, Radiological and Other Examinations as Well as to Surgical Procedures Which Require Empty Bowel.
Primary: Percentage of Participants With Successful Colon Cleansing — 94.29; 91.43 percentage of participants — p=<0.001
Breast Cancer
Primary: Event-free Survival — 88; 89 percentage of participants — p=0.85
Wilson's Disease
Primary: Safety and Efficacy — 37 participants
Type 2 Diabetes
Primary: Adjusted Mean Change From Baseline to Week 24 in Hemoglobin A1C (HbA1c) (Last Observation Carried Forward [LOCF]): Group 1 — -0.23; -0.58; -0.77; -0.89 Percent — p=0.0207
Deep Vein Thrombosis · Pulmonary Embolism
Primary: Rate of Composite of Adjudicated Venous Thromboembolic Event (VTE)-Related (Pulmonary Embolism and Symptomatic and Asymptomatic Deep Vein Thrombosis[DVT]) and All-cause…
Meningococcal Meningitis
Primary: Percentages of Subjects With Human Serum Bactericidal Assay (hSBA) Titers ≥ 1:8 Directed Against N. Meningitidis Serogroups A, C, W-135, and Y — 10; 35; 2; 34…
Pregnancy
Primary: Heart Rate — 146.0; 145.2; 142.5; 140.8 Beats per minute