12,372 trials
Adult Rhabdomyosarcoma · Embryonal Childhood Rhabdomyosarcoma · Embryonal-botryoid Childhood Rhabdomyosarcoma
Primary: Percentage of Patients With Low-risk Rhabdomyosarcoma in Subset 1 Failure Free at 5 Years Following Study Entry — 87; 67 Estimated percentage of participants
Pulmonary Disease, Chronic Obstructive
Primary: Change From Baseline in Exercise Endurance Time Post-dose at Week 12 of Each Treatment Period — 0.1; 25.1; 74.8; 30.7 Seconds — p=0.456
Diabetes · Hypertension · Dyslipidemia
Primary: Percent of Patients Achieving Hemoglobin A1C Goal, LDL Cholesterol Goal, and Systolic Blood Pressure Goal From the Enrollment Until the End of the Study — 40.8; 20.4…
Squamous Cell Carcinoma of Nasopharynx · Squamous Cell Carcinoma of Oropharynx · Squamous Cell Carcinoma of Hypopharynx
Primary: Incidence and / or Severity of Oral Mucositis — 19; 3 Grade 3-4 oral mucositis — p=0.05
Breast Neoplasms
Primary: Disease-Free Survival (DFS) at Month 36 Post-Randomization: Main Study — 0.90; 0.86 probability of DFS — p=0.00003
Venous Thrombosis
Primary: Incidence of Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or VTE-Related Death During 6 Months of Treatment — 0.0226; 0.0269 proportion…
Cystic Fibrosis · Pancreatic Insufficiency
Primary: Percent Coefficient of Fat Absorption (CFA) — 34.5; 82.7 Percent CFA — p=0.0013
Bone Metastases
Primary: Time to the First On-Study Skeletal-Related Event (Non-Inferiority) — 496.0; 625.0 Days — p=0.0007
Atrial Fibrillation
Primary: Major Bleeding, Annualized Rate of Subjects With Major Bleeds — 2.79; 3.59 percentage of subject-years — p=0.0055
Type 2 Diabetes Mellitus
Primary: Change From Baseline in Daily Insulin Dose at Week 24 — 19.0; 23.8 International Units (IU) — p=0.009
Rheumatoid Arthritis
Primary: Percent Change From Baseline in Synovial TNFa, CXCL13, IL-8, IL-6, IL-1b, IL-10, IP-10, BCL3, CD3E, DUSP4, FOXP3, CD79A, CD138, MMP-3, and MMP-1 After 12 Weeks of…
Elective Cranial Procedures With Dural Incision
Primary: Proportion of Treated Subjects Who Were Free of Intra-operative Cerebrospinal Fluid (CSF) Leakage From Dural Repair During Valsalva Maneuver, CSF Leak /…
Fever
Primary: Fever >=38C Within 32 Hours of Vaccination. — 14; 22 percentage of participants — p=0.053
Spinal Cord Injury · Hypogonadism
Primary: Dual Energy X-ray Absorptiometry (DXA) Assessment of Lean Tissue Mass (LTM) — 53.1; 50.5 kilograms — p=<0.01
Rheumatoid Arthritis
Primary: Proportion of Patients Achieving ACR20 at Week 24, Comparison Between Fostamatinib and Placebo — 36.2; 27.8; 21.1 Percentage of responders — p=0.004