Clinical Trial Search

Primary: Change From Baseline in the Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score — -12.83; -14.30; -15.57; -16.90 scores on a scale — p=0.224

Primary: Change From Baseline in the 24-item Hamilton Depression Scale Total Score At Week 8 — -11.30; -14.82; -15.42; -16.23 scores on a scale — p=<0.001

Primary: Change From Baseline in the 24-item Hamilton Depression Scale Total Score at Week 8 — -10.50; -12.04; -11.08; -13.47 scores on a scale — p=0.577

Primary: Change From Baseline in HAM-D-24 Total Score After 8 Weeks of Treatment — -10.3; -13.7; -15.8 units on a scale — p=0.0011

Primary: Change From Baseline in the Hamilton Anxiety Scale (HAM-A) Total Score — -9.87; -10.75; -10.68 scores on a scale — p=0.279

Primary: Change From Baseline in the Hamilton Anxiety Scale (HAM-A) Total Score at Week 8 — -13.16; -12.57 scores on a scale — p=0.518

Primary: Change From Baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score — -13.99; -14.61; -15.68; -15.82 scores on a scale — p=0.9070

Primary: Change in Glycosylated Hemoglobin (HbA1c) From Baseline to Week 30 — -1.13; -1.10 percent of hemoglobin — p=0.6273

Primary: Number of Participants Who Relapsed At End of LTFU Year 5 — 0 participants

Primary: Time to All Cause Death or First Hospitalization for Worsening Heart Failure — 1260.0; 1184.0 days — p=0.871

Primary: Physical Examination Findings — 758; 76; 484; 40 participants

Primary: Change From Baseline in the 24-item Hamilton Depression Scale Total Score at Week 6 — -13.87; -14.61 scores on a scale — p=0.407

Primary: Overall Survival (OS) — 17.54; 15.51 months — p=0.822

Primary: Overall Response Rate (ORR): Number of Participants Who Achieved Either Complete Remission (CR), Partial Remission (PR), or Marrow Complete Remission (mCR)…

Primary: Number of Participants With at Least 1 Adverse Event (AE) — 68; 58; 17; 15 participants