Phase 4 N=12 Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced Constipation
Constipation Drug Induced
Primary: Occurrence of Bowl Movement — 2; 2; 5 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=256 Meditation and Kundalini Yoga for Heightened Anxiety Related to COVID-19
Generalized Anxiety · Health Anxiety
Primary: GAD-7 — 4.7; 7.8; 4.9 score on a scale — p=0.071
N/A N=860 Umbilical Cord Milking in Non-Vigorous Infants
Birth Asphyxia
Primary: Number of Neonatal Participants Admitted to the NICU for Predefined Criteria — 199; 239; 53; 52 Participants — p=.87
N/A N=167 Multi-level Supermarket Discount Study
Obesity
Primary: Fruit Intake as Assessed by 24-h Dietary Recalls — 99.6; 112; 93.4; 127 grams
Early Phase 1 N=72 Developing a Mobile Method to Measure THC-induced Impairment
Measuring THC-induced Cognitive Impairment Using a Mobile Application
Primary: Simple Reaction Time — .365; .386; .396 Seconds
N/A N=226 A Proof-of-concept RCT of Version 3.0 of the Smoking Cessation Smartphone App "Smiling Instead of Smoking" (SiS)
Nondaily Smoking
Primary: End of Treatment Group Differences in Smoking Self-Efficacy Questionnaire (SEQ) — 63.81; 60.74; 58.45; 71.79 units on a scale — p=0.0219
N/A N=45 The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
Type 1 Diabetes
Primary: Change in C-peptide Area Under the Curve Measured by Mixed-meal Tolerance Test (MMTT) Between Group on GFD and Standard Gluten-containing Diet. — 1539; 1173 pmol*min/l…
Phase 3 N=2,980 Adjuvant Tamoxifen Compared With Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ
Breast Cancer
Primary: Number of Participants With Breast Cancer Recurrence, Including Recurrent DCIS and New Contralateral Tumours — 103; 120 Participants — p=0.33
N/A N=1,045 Using Behavioral Economics to Reduce Low-Value Care
Pre-Operative Testing for Cataract Surgery
Primary: Pre-Operative Testing Change — 87.4; 85.0; 86.1; 85.4 Percentage of patients with orders
N/A N=25 Auditory Processing in Spanish-English Bilinguals: Is Performance Better When Tested in Spanish or English?
Auditory Processing Disorder
Primary: Mean Difference in Scores for APD Assessment Using English vs. Spanish Materials — 97.40; 94.87; 97.14; 85.48 percentage of correctly identified stim — p=<0.01
N/A N=20 Mechanism of Action of tACS for the Treatment of MDD
Major Depressive Disorder · MDD
Primary: Change in the Amplitude of Left Frontal Alpha Oscillations Measured Durin Resting-state EEG Recordings From Baseline to Day 5 of Stimulation. — 0.042; 0.169…
N/A N=38 Assessing Inflammatory and Behavioral Pathways Linking PTSD to Increased Asthma Morbidity in WTC Workers
Asthma · PTSD
Primary: PTSD Checklist for DSM-5 (PCL-5) — 39.2; 36.4; 32.9; 34.3 score on a scale
Phase 4 N=201 Preventing Osteoporosis Using Denosumab
Osteoporosis, Postmenopausal · Osteoporosis · Osteoporotic Fractures
Primary: Bone Density of the Total Hip — 4.62; -0.19; 3.74; 0.48 Percent change — p=.007
N/A N=18,770 Intervention to Reduce Early (Peanut) Allergy in Children
Food Allergy Peanut · Food Allergy in Infants
Primary: Pediatric Clinician Adherence to Guidelines — 7607; 3231; 62; 7 infants — p=<0.001
Phase 2 N=113 Cemiplimab and ISA101b Vaccine in Adult Participants With Recurrent/Metastatic Human Papillomavirus (HPV)16 Cervical Cancer Who Have Experienced Disease Progression After First Line Chemotherapy
Cervical Cancer
Primary: Objective Response Rate (ORR) — 17.7 Percentage of Participants