Phase 2 N=15 Study of Quetiapine Treatment for Cannabis Dependence
Cannabis Dependence
Primary: Maximum Tolerated Dose of Quetiapine — 197 milligrams
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=228 A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)
Post-operative Nausea · Post-operative Vomiting
Primary: Area Under the Concentration-time Curve of Aprepitant From Time 0 to the Last Measurable Concentration (AUC0-last) Following Administration of 125 mg Dose Equivalent in…
Phase 2 N=76 Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery
HIV-1 Infection
Primary: Change in CD8+ T-cell Activation From Baseline to Week 14/16 — 3.24; 0.52 percentage of cells — p=0.030
Phase 2 N=19 Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
Cocaine Dependence
Primary: Change in Visual Analog Questionnaire (VAQ) Score — 0.38; 3.75; 0.38; 40.63 units on a scale — p=<0.01
Phase 2 N=37 Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer
Endometrial Adenocarcinoma · Endometrial Adenosquamous Carcinoma · Endometrial Clear Cell Adenocarcinoma
Primary: Objective Tumor Response According to RECIST — 2 Participants
Phase 2 N=69 Efficacy and Safety of AQX-1125 in IC/BPS
Interstitial Cystitis · Bladder Pain Syndrome
Primary: Change From Baseline in the Average Daily Bladder Pain Score (e-Diary) — 6.4; 6.7; -2.4; -1.4 units on a scale — p=0.061
Phase 2 N=15 A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma
Severe, Refractory Asthma · Airway Inflammation · Airflow Obstruction
Primary: 16 Weeks - Juniper Asthma Quality of Life Questionnaire (AQLQ) Score — 4.7; 4.6 units on a scale
Phase 2 N=36 [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers
Uterine Cervical Neoplasms · Endometrial Neoplasms · Anus Neoplasms
Primary: Percent Difference From Baseline IMRT Plan (%) — -4.7; -9.3; -14.2; -13.4 Percent difference (%)
Phase 2 N=639 Efficacy and Safety Study of Laninamivir Octanoate TwinCaps® Dry Powder Inhaler in Adults With Influenza
Influenza
Primary: Time to Alleviation of Influenza Symptoms — 102.30; 103.20; 104.10 hours — p=0.251
Phase 2 N=19 Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma
Recurrent Osteosarcoma
Primary: Disease Control Success — 0 participants
Phase 2 N=129 Orvepitant (GW823296) in Adult Post Traumatic Stress Disorder
Post-Traumatic Stress Disorder
Primary: Change From Baseline in the 17-item Clinician Administered Posttraumatic Stress Disorder (PTSD) Scale (CAPS) Total Severity Score at Week 12 — -25.75; -31.38 Score on…
Phase 2 N=39 Bevacizumab, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Stage II or III Multiple Myeloma
Multiple Myeloma in Relapse · Stage II Multiple Myeloma · Stage III Multiple Myeloma
Primary: Confirmed Anti-tumor Response Rate (Complete Response and Partial Response) to the Combination of Bevacizumab and Lenalidomide — 64 percentage of participants
Phase 2 N=35 Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
Marijuana Dependence
Primary: Plasma THC — 6; 53; 70; 7 ng/mL
Phase 2 N=60 Doxorubicin Hydrochloride, Cyclophosphamide, and Filgrastim Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation With or Without Trastuzumab in Treating Patients With Breast Cancer Previously Treated With Surgery
Estrogen Receptor-positive Breast Cancer · HER2-positive Breast Cancer · Stage IA Breast Cancer
Primary: Disease-free Survival Following a Dose-intensive Weekly Regimen of Adriamycin + Oral Cyclophosphamide Augmented With G-CSF Support Followed by Abraxane and Herceptin…
Phase 2 N=163 Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer
Dysphagia · Lung Cancer · Pain
Primary: Change in Radiation Esophagitis-related Pain at 4 Weeks as Measured by the Numerical Rating Pain Scale for Pain on Swallowing (NRPS) — 1; 1; 1 units on a scale — p=0.92