Phase 3 N=701 Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus (0431-020)(COMPLETED)
Diabetes Mellitus, Type II
Primary: Change From Baseline in Hemoglobin A1C (A1C) at Week 24 — -0.67; -0.02 Percent — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=2,013 Dabigatran Etexilate Compared With Enoxaparin in Prevention of Venous Thromboembolism (VTE) Following Total Hip Arthroplasty
Venous Thromboembolism
Primary: Number of Participants With Total Venous Thromboembolic Event and All-cause Mortality During Treatment Period — 61; 69 Participants — p=< 0.0001
Phase 3 N=441 Sulfonylurea Add-on Study in Patients With Type 2 Diabetes Mellitus (0431-035)
Diabetes Mellitus, Type 2
Primary: Change From Baseline in A1C at Week 24 — -0.45; 0.28 Percent — p=<0.001
Phase 3 N=2,596 Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement
Arthroplasty, Replacement, Knee · Thromboembolism
Primary: Number of Participants With Total Venous Thromboembolic Event and All-cause Mortality During Treatment Period — 188; 219; 163 Participants — p=0.0234
Phase 3 N=2,076 RE-MODEL Dabigatran Etexilate 150mg or 220mg Once Daily (o.d.) Versus (v.s.) Enoxaparin 40mg o.d. for Prevention of Thrombosis After Knee Surgery
Arthroplasty, Replacement, Knee · Thromboembolism
Primary: Number of Participants With Total Venous Thromboembolic Event and All-cause Mortality During Treatment Period — 183; 213; 193 Participants — p=0.6648
Phase 3 N=763 A Study of an Investigational Zoster Vaccine in Subjects With a History of Varicella (Chickenpox) Given Concomitantly With Another Vaccine (V211-011)
Herpes Zoster
Primary: Varicella-zoster Virus (VZV) Glycoprotein Enzyme-linked Immunosorbent Assay (gpELISA) Antibody Responses — 553.5; 588.7 gpELISA units/mL
Phase 3 N=101 A Study of an Investigational Zoster Vaccine, in Subjects With a History of Herpes Zoster (V211-014)
Herpes Zoster
Primary: Vaccine-related Serious Adverse Experiences (SAEs) for 28 Days Postvaccination — 0; 0; 100; 101 Participants
Phase 3 N=25 PegIntron Versus Adefovir in the Treatment of Chronic Hepatitis B (CHB) e Antigen Positive Patients in Taiwan (P04498/MK-4031-278)
Hepatitis B, Chronic (CHB)
Primary: Number of Participants With a Combined Response Consisting of All Three Responses - (a) Serological Response, (b) Virological Response, and (c) Biochemical Response — 0…
Phase 3 N=500 Lurasidone HCl: A Phase 3 Study of Patients With Acute Schizophrenia
Schizophrenia
Primary: Change in Total PANSS Score From Baseline to the End of the Double Blind Phase — -19.2; -23.4; -20.5; -17.0 scores on a scale — p=<0.05
Phase 3 N=339 Comparison of Two Basal Insulins for Patients With Type 2 Diabetes Taking Oral Diabetes Medicines and Exenatide
Diabetes Mellitus, Type 2
Primary: Change From Baseline in Hemoglobin A1C (HbA1c) at Endpoint (Last Observation Carried Forward [LOCF]) — 8.48; 8.47; -1.21; -1.43 percent of glycosylated hemoglobin
Phase 3 N=320 Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain
Chronic Pain
Primary: Pain Intensity Difference (PID15) At 15 Minutes — 0.82; 0.59 Units on a scale — p=<0.0001
Phase 3 N=137 An Extension Study Evaluating the Long-Term Safety and Tolerability of Degarelix One-Month Depots in Prostate Cancer
Prostate Cancer
Primary: Participants With Markedly Abnormal Change in Vital Signs and Body Weight — 3; 5; 10; 9 participants
Phase 3 N=44 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes
Dental Plaque
Primary: Control Established Plaque in Adults — 2.42; 2.45 Units on a scale — p=<0.05
Phase 3 N=38 Evaluation of the Performance of Non-molded Soft Contact Lenses
Ametropia
Primary: Visual Acuity — 0.01; -0.07 logMAR
Phase 3 N=436 ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)
Alcoholism
Primary: Number of Subjects Reporting at Least 1 Treatment-emergent Adverse Event (TEAE) While on Study — 336; 53 Participants