12,372 trials
Psoriatic Arthritis
Primary: Percentage of Participants With American College of Rheumatology 50 (ACR50) Response Comparison Between Treatment Groups Using Non-responder Imputation at Week 16 (Full…
Pneumococcal Infections · Pneumococcal Conjugate Vaccine
Primary: The Serotype-specific Immunoglobulin G (IgG) Geometric Mean Concentrations (GMCs) for Each of the Pneumococcal Serotypes Measured in Cohorts 2, 3 and 4 Compared to IgG…
Diabetic Macular Edema
Primary: Mean Change in Visual Acuity — 15; 14 Letter Score
Temple Hollowing
Primary: Percentage of Participants With ≥ 1-grade Improvement From Baseline in the Validated Allergan Temple Hollowing Scale (ATHS) Based on Evaluating Investigator (EI)…
Type 1 Diabetes Mellitus
Primary: Change in C-peptide ln(AUC+1) Standardized by Duration of the Mixed Meal Tolerance Test (MMTT) — -0.2112; -0.0859; -0.2185; -0.0800 pmol/mL — p=<0.001
Asthma
Primary: Annual Asthma Exacerbation Rate in Patients on Medium to High-dose ICS-LABA With Uncontrolled Asthma for Baseline Eosinophils >=300/uL — 0.49; 1.88 events/patient-year…
Chronic Kidney Disease
Primary: Proportion of Transdermal Derived Glomerular Filtration Rate (tGFR) Values Within 30% of the nGFR Plasma-derived Indexed Glomerular Filtration Rate (nGFR) Values — 0.96…
Pre-Eclampsia · Hypertension in Pregnancy · Pregnancy Complications
Primary: Mean Systolic Blood Pressure During Hour After Study Drug — 147; 152 mmHg
Relapsed or Refractory Multiple Myeloma
Primary: Overall Response Rate (ORR) Per International Myeloma Working Group Uniform Response Criteria (IMWG-URC) — 86.3; 82.5 percentage of participants — p=0.0666
Eosinophilic Gastritis · Eosinophilic Duodenitis
Primary: The Safety and Tolerability of Lirentelimab by Evaluating Adverse Events Assessed Using the CTCAE Version 5.0 — 66; 75; 33; 29 Participants
Osteoporosis, Postmenopausal
Primary: Percent Change From Baseline in LS-BMD at Week 52 — 4.76; 4.54 percentage of change from baseline
Diabetes Mellitus, Type 2
Primary: Dapagliflozin Versus Placebo: Adjusted Mean Change From Baseline in HbA1c at Week 26 — -0.62; 0.41 Percentage HbA1c — p=< 0.001
Delirium
Primary: Days Without Delirium — 2.54; 3.38 delirium free days — p=0.22
Barth Syndrome
Primary: Part 1: Distance Walked During the 6-Minute Walk Test (6MWT) by Visit — 400.1; 412.6; 443.1; 443.9 meters
Bipolar I Disorder
Primary: Change From Baseline to Week 4 in Young Mania Rating Scale (YMRS) Total Score — -14.0; -10.0 Change from Baseline in YMRS Total Score