Clinical Trial Search

Primary: Drug Liking: Area Under Effect Curve (AUE) From 0-2 Hours — 88.3; 100.3; 124.7 hrs*mm — p=<0.0001

Primary: Response to EDQ Question Number 5, "Rate the Degree to Which You Would Like to Take the Drug Again" — 0; 1.714; 2.143; 2.286 units on a scale

Primary: Positive Subjective Drug Effects (i.e., Drug "Liking"). — 52.1; 57.5; 71.8; 71.5 units on a scale — p=.0001

Primary: Drug Liking at .5 Hours — 66.0; 74.7; 47.7; 40.9 score on a scale

Primary: Balance of Effects- Drug Liking VAS: Peak Effect (Maximum Effect [Emax]) and Minimum Effect (Emin) — 57.8; 78.6; 82.2; 57.2 mm — p=<0.0001

Primary: Drug Liking Visual Analog Scale (VAS) — 56.4; 84.9; 59.6; 64.6 score on a scale

Primary: Drug Liking "at This Moment" Visual Analog Scale (VAS) — 54.1; 83.8; 58.9; 58.4 score on a scale

Primary: Emax - Maximum Drug Liking — 54.5; 75.0; 72.1; 75.6 score on a scale

Primary: Subjective Effects: Maximum Effect (Emax) and Minimum Effect (Emin) of High Visual Analog Scale (VAS) in Dose Selection Phase — 85.0; 42.0; 75.5; 94.0 units on a scale

Primary: Drug's Breakpoint — 1200; 10; 1100; 1200 number of clicks on a mouse

Primary: 3 Scores on the Addiction Research Center Inventory (ARCI) — 7.6; 5.4; 5.2; 3.3 scores on a scale

Primary: Bipolar Visual Analog Scale (VAS) for "Drug Liking" Maximum Effect (Emax). — 54.30; 90.85; 72.53; 76.05 Score on a 100 mm scale — p=<0.0001

Primary: Breakpoint — 25; 400; 1400; 850 Mouse Clicks

Primary: Drug Liking: Peak Effect (Emax) — 51.6; 70.1; 85.5; 59.3 mm — p=<0.0001

Primary: Subjective Ratings of "Good" Drug Effect — 37; 35; 35 units on a scale

Primary: Change in Cold Pressor Test (CPT) Latency — 21.40; 10.94; 2.07; 15.17 percent change from Day 1 baseline

Primary: Bipolar Visual Analog Scale (VAS) for "Drug Liking" Maximum Effect (Emax). — 51.98; 79.37; 61.95; 61.39 Score on a scale — p=<0.0001

Primary: Intensity of Drug Purchase Task (DPT) — 172.20; 89.90; 60.83; 94.50 number of puffs

Primary: Bipolar Visual Analog Scale (VAS) for "Drug Liking" Maximum Effect (Emax). — 54.89; 87.40; 57.89; 63.62 Score on a 100 mm scale — p=<.0001

Primary: Drug Like/Dislike Effect at 30 Minutes Post Dose (E 30 Min) — 11.7; 14.7 score on a scale

Primary: Drug Liking: Peak Effect (Emax) — 50.9; 60.5; 51.3; 92.8 mm — p=0.0001

Primary: Number of Participants Retained in Study — 18 participants

Primary: Number of Self-administered Puffs of Smoked Cannabis Containing Active THC Concentrations Compared to Placebo Under Controlled Laboratory Conditions — 2.00; 2.67; 3.60…

Primary: Pharmacodynamics (PD): Maximal Effect Score (Emax) of Bipolar Drug Liking Visual Analog Scale (VAS) Scores — 53.0; 85.4; 68.6; 73.3 millimeter (mm)

Primary: Peak Positive Subjective Responses to Placebo. — 3.3; 2.3 units on a scale

Primary: Percent Change in Average Daily Cigarette Use Per Day From Baseline — 36.8; 80.36 % reduction in cigarettes per day

Primary: Drug Effect Questionnaire - Stimulatory Effects — 39.37; 33.48; 32.35; 33.23 units on a scale — p=0.93

Primary: Treatment Phase: Drug Liking (Maximum Effect [Emax]) "At This Moment" as Assessed Using Bipolar Visual Analogue Scale (VAS) — 56.7; 57.3; 56.5; 88.5 score on a scale

Primary: Change in Subject-Rated Outcome: Visual Analog Scale (VAS) Drug Liking — 7.40; 39.00; 40.80; 24.50 Score on a scale — p=<0.0001

Primary: Drug Self-administration — 350; 255; 223; 113 Clicks on a computer mouse