N/A N=170 Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Acute Psychological Stress
Primary: Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) — 0.265; 0.287 mL/(kg·min)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
Phase 4 N=92 Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
Stress, Psychological · Inflammation · Cortisol
Primary: Change in Interleukin-6 (IL-6) — .05; .16; .31; .24 log(picograms/mL)
N/A N=53 Stress in Inflammatory Bowel Disease
Inflammatory Bowel Diseases · Psychological
Primary: Retention Rate — 23; 25; 19; 22 Participants
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=23 Stress and the Nervous System
Autonomic Nervous System · Baroreflex · Stress, Physiological
Primary: Cardiovagal Baroreflex Sensitivity (Modified Oxford Technique) — 17.75; 16.90; 14.42; 17.27 ms/mmHg
N/A N=44 Challenging the Inflammatory Response System in Insomnia Disorder
Insomnia
Primary: Inflammatory Response to Physiological Challenge- Change in Plasma Levels of IL-6 — 1.5013; 2.1626; 2.5911; 2.7269 pg/mL
Phase 4 N=10 Brain and Stress Study
Stress, Psychological · Motivation
Primary: Change in Response Bias During the Probabilistic Reward Task — 0.195; 0.203 Ratio (Response Bias Score) — p=0.856
Phase 2 N=68 Academic Stress and Proinflammatory Cytokines: Omega-3 Intervention
Stress-related Changes in Inflammation
Primary: Serum ln(IL-6) — 0.054; 0.051 ln(pg/mL) — p=0.97
Phase 2 N=20 An Inflammatory Challenge Using Endotoxin
Alcohol Use Disorder · Inflammatory Response · Craving
Primary: Cue-induced Craving — 4.5004; 7.9081; 4.5004; 5.6178 score on a scale — p=0.036
N/A N=323 Stress, Salt Excretion, and Nighttime Blood Pressure
Blood Pressure · Psychological Stress
Primary: Ratio of Awake-to-asleep Urinary Sodium Excretion Rate (Aim 1) — 1.4 Ratio of awake-to-asleep — p=0.0032
Phase 1 N=64 Lipopolysaccharide (LPS) Challenge in Depression
Major Depressive Disorder
Primary: Change in Snaith-Hamilton Pleasure Scale (SHAPS) — 38.4; 33.2; 27.2; 26.2 units on a scale
N/A N=6 Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Sedentary Behavior · Cardiovascular Risk Factor · Mental Stress
Primary: Mean Change in Brachial-femoral Pulse Wave Velocity (bfPWV) — -0.26; 0.22 m/s
N/A N=90 Management of Anger in Patients With Acute Myocardial Infarction (MAPAMI)
Myocardial Infarction
Primary: Difference in Flow-mediated Dilation in the Brachial Artery in the Base and After the Treatment. — 11.24; 7.70 percent change dilatation — p=0.05
Phase 1 N=34 Imaging the Neuroimmune System in PTSD
Post Traumatic Stress Disorder
Primary: Baseline TSPO Availability — 5.11; 4.75; 5.07; 4.38 mL/cm3
N/A N=99 Investigating the Neural Systems That Support the Beneficial Effects of Positive Emotion on Stress Regulation
Behavior
Primary: Mood Ratings (Pos) — 1.34; 1.04; .96; .83 units on a scale
N/A N=12 Endocannabinoid and Psychological Responses to Yoga in Healthy Adults
Healthy
Primary: Change in Plasma Concentration of N-arachidonoylethanolamine — -.013; -.655 pmol/mL
N/A N=112 The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
PTSD
Primary: Change From Baseline to Post-Intervention in 24-hour Heart Rate Variability (HRV) Estimated From the Standard Deviation of the Interbeat Interval of Normal Sinus Beats…
N/A N=1,418 Effects of Arousal and Stress in Anxiety
Healthy Volunteers
Primary: Go Correct Hits Followed by Button Press — 90.9; 91.6 Percentage of correct responses
N/A N=110 Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
Sedation · Critical Illness · Respiration, Artificial
Primary: Levels of Serum Cortisol — 13.13; 15.93; 11.56; 16.07 µg/dL
N/A N=270 The Biology of Resilience
Oxytocin · Placebo
Primary: Systolic Blood Pressure Change From Baseline to Second Stress Task Experience - Autonomic Stress Response Measure — 9.4; 12.9; 11.3; 11.1 mm Hg — p=0.03
Phase 4 N=95 Stress and Inflammation in Late-Life Depression
Depression · Inflammation
Primary: IL-6 Levels — 5.25; 18.24; 3.69; 6.84 pg/mL — p=.44
N/A N=72 Does Treating Anxiety Symptoms With ACT Improve Vascular Inflammation and Function?
Anxiety
Primary: Beck Anxiety Inventory (BAI) — 18.750; 17.464; 13.317; 16.154 score on a scale — p=0.02
N/A N=120 Stress & Anxiety Dampening Effects of a Probiotic Supplement Compared to Placebo in Healthy Subjects
Healthy · Stress, Psychological
Primary: Change of the Heart Rate (HR) in Response to the Trier Social Stress Test (TSST) — 74.84; 74.34; 88.15; 86.69 bpm — p=0.757
Phase 2 N=39 Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
Cortisol Resistance · Negative Feedback · ACTH
Primary: Proportion of Suppressors After Dexamethasone — 0; 1 Participants — p=0.4872
N/A N=17 Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
Middle-aged Adults · Major Depressive Disorder
Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05
Phase 2 N=24 Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects
Healthy Volunteers
Primary: Change in The Profile of Mood States - Bipolar Version (POMS - Bi) Composed-Anxious Subscale — -6.8; -11.9 score on a scale
N/A N=58 Cranial Electrotherapy Stimulation and Acute Stress
Anxiety State
Primary: Change From Baseline in Heart Rate During Stressful Lethal Force Decision Making Task — 98.5; 111; 100.0; 114 bpm — p=.012
Phase 3 N=36 The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
Fibromyalgia
Primary: Change in Ratio of Choline/ Creatine (CHO/CR) in the Brain From Baseline to 3 Hrs Post-endotoxin Administration — -.0021; -.0058 ratio
N/A N=40 Mindfulness for Resilience in Early Life
Adolescent With Early Life Stress · Resilience
Primary: Cortisol Reactivity — -0.21; 0.34; 0.05; -0.08 μg/dL — p=<.05