Phase 2 N=25 Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults
Cough
Primary: Lung Volume Initiation — 23.3 % Vital Capacity, relative to EEL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=119 Airway Protective Mechanisms in PD (R01)
Parkinson Disease
Primary: Respiratory Sensitivity — 0.22; 0.22; 0.21; 0.22 scores on a scale / CmH2O — p=<.0001
Phase 4 N=81 Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Airway Reflexes, Protective · Recovery After Neuromuscular Block · Anesthetic Recovery
Primary: Recovery of Ability to Swallow After Neostigmine/Glycopyrrolate Antagonism of Rocuronium Paralysis. — 16; 25; 10; 6 participants — p=0.11
N/A N=30 Predictors of the Ability to Protect the Airway in Long-term Ventilated Patients
Swallowing Disorder · Aspiration · Long Term Ventilation
Primary: Muscle Strength — 20; 10 participants
N/A N=133 Mechanisms of Upper Airway Obstruction
Obstructive Sleep Apnea
Primary: Pharyngeal Critical Pressure (Pcrit) — 1.26; -1.42; -1.06 cm H2O — p=.80
Phase 2 N=65 Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
Parkinson's Disease · Dysphagia · Dystussia
Primary: Change in Voluntary Cough Peak Flow — 0.17; 0.51 l/s
N/A N=6 Sub-study to Spinal Cord Stimulation to Restore Cough
Spinal Cord Injuries · Spinal Cord Diseases · Paralysis
Primary: The Effects of Electrical Spinal Cord Stimulation (SCS) on Airway Pressure Generation While Using Temporarily Placed Parallel Wire Leads and Implanted Disc Electrodes…
N/A N=25 Neurostimulation for the Relief of Acute Bronchoconstriction
Asthma
Primary: Safety- Number of Participants With Adverse Events — 16 Participants
N/A N=15 Assessment of Cough Reflex in Lung Transplant Recipients
Complication of Transplanted Lung
Primary: Number of Coughs — 7.3 Coughs — p=<0.01
N/A N=62 Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation
Respiration Disorder · Respiratory Failure · Weaning Failure
Primary: Magnitude of Inspiratory Premotor Potentials — 1.2; 2.1 µV
Phase 2 N=14 Cough and Swallow Rehab Following Stroke
Ischemic Stroke
Primary: Maximum Expiratory Pressure — 104.31 cm H2O (pressure measurement) — p=.001
Phase 4 N=142 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Coughing
Primary: Coughing Grade — 0.6; 1.4 units on a scale
Phase 2 N=49 Normal Breathing and Swallowing in Healthy Volunteers
Healthy
Primary: Reflexive Cough Testing (With Urge-to-Cough) — 3; 5 units on a scale
N/A N=1,705 ED Lung Protective Ventilation to Reduce Complications
Mechanical Ventilation · Ventilator-associated Conditions · ARDS
Primary: Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department — 171; 38 participants
Phase 4 N=18 The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
Airway Complication of Anaesthesia · Healthy
Primary: Upper Airway Closing Pressure — -9.83; -10.77 cm H20
N/A N=164 Soiled Airway Tracheal Intubation and the Effectiveness of Decontamination by Paramedics
Airway Management · Intubation, Intratracheal · Laryngoscopy
Primary: Difference in First-pass Intubation Success Rates Before and After SALAD Training — 44; 74 Participants
N/A N=76 Evaluating Air Leak Detection in Intubated Patients
Critical Care
Primary: CO2 Leakage Above the ETT Cuff, Measured Over Time. — 0.09; 0.22 [CO2 mmHg*hour]/hour
Phase 2 N=54 Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine Colonoscopy
Airway Obstruction · Apnea · Hypopnea
Primary: RI Events in the cNEP Group Compared to the no cNEP Group, Where RI is Defined as Either: i Oxygen Saturation < 90% or ii. Apneas/Hypopneas of > 15 Sec Duration i…
N/A N=15 The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Mechanical Ventilation · Airway Patency · Respiratory Depression
Primary: Inspiratory Airflow — 0.36; 0.47; 0.44 L/s
Phase 4 N=40 Effect of Neuromuscular Blockade and Reversal on Breathing
Respiratory Insufficiency
Primary: Breathing Increase Due to a Reduction in Inspired Oxygen Saturation (Hypoxic Ventilatory Response) — 0.66; 0.43; 0.54; 0.34 L/min/% desaturation
N/A N=32 Effort of Breathing Guided Ventilator Protocol
Ventilators, Mechanical · Work of Breathing
Primary: Percentage of Protocol Recommendations Which Are Accepted by the Clinical Provider — 76 percentage adherant
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
Early Phase 1 N=5 The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease · Chronic Bronchitis
Primary: Number of Coughs Following Capsaicin Inhalation Challenge at Baseline and Following 30 Days of Treatment With Spiriva (Baseline and 30 Days) — 2.5 coughs per dose of…
Phase 2 N=44 Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
Cough · Parkinson's Disease
Primary: Peak Expiratory Flow Rate — 4.34; 3.92 Liters of air/second
N/A N=28 Prophylactic Bronchoscopy After Inhalation Injury in Burn Patients
Inhalation Injury · Pneumonitis · Pneumonia
Primary: All Cause Mortality — 0; 1 participants
N/A N=10 Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
Healthy Volunteers
Primary: Changes in Airway Blood Flow After 180μg Albuterol by Inhalation (ΔQaw) vs Baseline — 16.8; 14.5; -0.2; 2.0 changes from baseline in μl.min-1.ml-1
N/A N=58 Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients
Cough
Primary: Brainstem Neural Activations to Capsaicin — 0.09; 0.39; -0.14; 0.44 Percentage change in BOLD signal — p==0.0028
N/A N=159 Safety Study of Airway Clearance Techniques in Infants.
Gastro-esophageal Reflux
Primary: Number of Refluxes — 0.48; 1.14; 1.62 number of refluxes
N/A N=10 PEEP Mask for Tracheobronchomalacia-Induced Cough
Tracheobronchomalacia
Primary: Change in Cough Severity as Measured by the Cough Visual Analog Scale (VAS) — -50.67 units on a scale — p=0.108
N/A N=7 Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Deglutition Disorders · Respiratory Distress Syndrome In Premature Infants · Respiratory Aspiration
Primary: Pharyngeal Phase Dysphagia — 7; 7 Participants