Clinical Trial Search

Primary: Percentage of Screen Eligible Who Enroll — 28; 5 Participants

Primary: Percent of New Alcohol Use Disorder (AUD) Diagnosis Episodes That Meet Criteria for AUD Treatment Engagement Among Patients With a New AUD Diagnosis Who Are Empaneled to…

Primary: Percentage of Participants Demonstrating Alcohol Abstinence in the Control (Midazolam) Group Versus the Active (Ketamine) Group — 68.6; 98.6 percentage of participants

Primary: Number of Serious Adverse Events (Safety and Tolerability) — 1; 1 Adverse Events

Primary: Change in Alcohol Consumed — -32.72; -6.95 grams

Primary: Heavy Drinking Days Per Week Change — -1.76; -2.3 Mean heavy drinking days per week

Primary: Alcohol Craving — 6.44; 6.26 score on a scale — p=0.784

Primary: Trough CBD Plasma Levels — 0; 0.7 CBD (ng/mL)

Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…

Primary: Timeline Follow Back (TLFB) — -0.82; -0.71 drinks per drinking day

Primary: Recruitment Feasibility — 3 Participants

Primary: Time to Relapse — 16; 43 days

Primary: Mean Number of Drinks Consumed Per Week — 40.82; 29.62; 12.12; 23.86 Standard Drinking Units per Week — p=0.002

Primary: Weekly Change in Drinking — -11.4; -22.2; -39.6; -29.3 score on a scale

Primary: Percent Abstinent Days — 3.13; 100 Percentage of days

Primary: Percent Heavy Drinking Days — 67.4777; 65.65447; 53.88376; 42.96028 percent of heavy drinking days

Primary: Craving for Alcohol in Alcohol Dependence With Citalopram Compared to Placebo — 21; 30.4; 10.8; 10.6 score on a scale

Primary: Percentage of Heavy Drinking Days, PHDD — 24.4; 21.4; 21.3 percentage of heavy drinking days — p=0.688

Primary: Number of Participants With Independent Adjudication Committee (IAC) Adjudicated Event of Exacerbation of Disease (EEDS) — 25; 29; 87; 88 Participants — p=0.746

Primary: Change in Heavy Drinking Days Per Week for Dutasteride vs. Placebo Groups — -2.24; -1.41 Heavy Drinking Days per week — p=0.012

Primary: Change in Percent Heavy Drinking Days (%HDDs) Over the Past 30 Days From Baseline to 3 Month Follow-up, Assessed Using the Timeline Follow-Back — -46.4; -38.4 change in…

Primary: Number of Participants With Adverse Events (AEs) — 18; 15 Participants

Primary: Brief Alcohol Counseling Rate — 57; 11 participants per 10,000 with visits — p=<.001

Primary: Concentrations of Glx (i.e., Glutamate + Glutamine) — 18.76; 18.57 mmol/kg — p=0.33

Primary: Quick Inventory of Depression- Self Report 16 — 9.3; 8.9 units on a scale

Primary: Alcohol Time Line Followback (30)- Heavy Drinking Episode Days in the Past 30 Days — 7.9; 4.3 heavy drinking days

Primary: Number of Drinks Per Week — 19.7; 23.7 Number of drinks per week — p=0.0130

Primary: Negative Affect — 2.91; 2.47 units — p=.62

Primary: Audit-C Score on a Scale — -1.0; -2.3; -1.0 score on a scale

Primary: Weekly Percentage of Heavy Drinking Days — 51.5; 52.9 percentage of days per week