Phase 4 N=16 Pathophysiology of Post Amputation Pain
Amputation Stumps · Neuroma
Primary: Change in Pain — -0.3; -2; -1; 1.3 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=33 N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
Diabetes Mellitus · Critical Limb Ischemia · Lower Limb Amputation Knee
Primary: Change in Postoperative Laser-Assisted Fluorescent Angiography (LAFA) Perfusion. — 0.060; 0.096; 0.045; 0.031 percentage of defect
Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
Phase 1 N=6 Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Peripheral Artery Disease · Vascular Disease · Critical Limb Ischemia
Primary: Number of Participants With Treatment-related Adverse Events Occurring During the Enrollment Period as Assessed by the Investigator Using the CTCAE 4.0 Scale. — 2; 0…
N/A N=18 Evidence Based Amputee Rehabilitation (EBAR) Program
Amputation Stumps · Diabetes Mellitus
Primary: Amputee Mobility Predictor — 36.4; 35.3; 41.7; 35.6 Points
N/A N=10 AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized
Wounded Warrior · Limb Shortening · Amputation
Primary: Efficacy of Autologous Fat Transfer at Pain Modulation at Respective Amputation Sites — 1.3; 0 score on a scale
N/A N=15 ICG Fluorescence Imaging in Lower Extremity Amputation Patients
Trauma Injury
Primary: Total Bone Blood Flow (TBBF)-Post Osteotomy — 4.9 mL/min/100g
N/A N=144 Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study
Post-Amputation Phantom Limb Pain
Primary: Change From Baseline in Average Daily Phantom Pain Intensity — 0.5; 0 score on a scale
N/A N=4,549 Longitudinal Study of Weight Change Following Lower Limb Amputation
Amputation Wound · Traumatic Amputation of Toe · Dysvascular Amputation of Lower Limb
Primary: % Weight Change From Baseline — 5.5; 0.9 % weight change
N/A N=56 AMPLEX Ankle Fusion and Hindfoot
Arthrodesis Surgery Involving the Hindfoot or Ankle
Primary: Proportion of Subjects Who Met All Five Criteria for Subject Performance Composite (SPC) Endpoint — 79.5; 35.3 percentage of subjects
N/A N=147 Self-management to Improve Function Following Amputation
Amputation, Limb Loss
Primary: Short Musculoskeletal Function Assessment (SMFA) — 32.34; 30.19 score on a scale
N/A N=12 Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
Amputation, Surgical · Amputation, Traumatic · Phantom Limb Pain
Primary: Average Pain Intensity Change From Baseline 1 Month Post-intervention — 0; 0; 0 score on a scale
N/A N=16,746 This Study Combines Data From 3 Other Studies Testing Empagliflozin in Patients With Diabetes or With Chronic Heart Failure. The Study Looks at the Numbers of Patients Who Had Lower Limb Amputations
Diabetes Mellitus, Type 2
Primary: Incidence Rate of Lower Limb Amputation (LLA) — 0.40; 0.48; 0.27; 0.23 Patients with events per 100pt-yrs — p=0.9276
N/A N=131 Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ulcers
Diabetic Foot · Diabetic Ulcer of Left Foot · Diabetic Ulcer of Right Foot
Primary: Proportion of Patients Receiving Guideline-concordant Vascular and Infectious Disease Care Processes — 14; 6 Participants
Phase 2 N=13 Qbrexza Cloths for Hyperhidrosis of Amputation Sites
Amputation · Hyperhidrosis
Primary: ASDD-m Sweat Severity Score — 1.2; 3.6 score on a scale of 0-10
N/A N=16 Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Phantom Limb Pain · Postoperative Pain · Neuroma
Primary: Average Phantom Limb Pain (PLP) Score — 4.1; 3.1; 2.2; 3.0 score on a scale
N/A N=272 Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications
Amputation · Amputation; Postoperative, Sequelae · Wound Dehiscence
Primary: Overall Rate of Wound Complications — 26; 31 Participants
N/A N=50 Forensic-medical Aspects of Lower Limb Prosthetics: An Observational Study
Amputation
Primary: Questionnaire: Trinity Amputation Prosthesis Experience Scale (TAPES) — 57; 8; 40 units on a scale
N/A N=14 Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation
Amputation
Primary: Stability of Joint Position Control in Free Space — 4; 3.1 Distinct synergy activations
N/A N=15 Weight Loss Intervention for Individuals With Lower Extremity Amputation
Lower Extremity Amputation
Primary: Number of Individuals That Were Randomized of Those Contacted (Feasibility) — 15 participants
N/A N=33 Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
Post-Amputation Pain · Phantom Limb Pain · Residual Limb Pain
Primary: Proportion of Group 1 (Treatment) and Group 2 (Control) Subjects That Achieved ≥ 50% Reduction in All Qualifying Areas of Pain in the First 4 Weeks of Treatment — 7; 2…
N/A N=31 Physical Activity Behavior Change for Older Adults After Dysvascular Amputation
Amputation · Diabetes Mellitus, Type 2 · Peripheral Artery Disease
Primary: Retention Rate — 14; 13 Participants
Phase 4 N=144 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Phantom Limb Pain
Primary: "Average" Phantom Limb Pain Intensity 4 Weeks Following Initiation of an Ambulatory Continuous Peripheral Nerve Block (as Measured by the Numeric Rating Scale Within the…
N/A N=4 Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Phantom Limb
Primary: Stimulation Thresholds to a Variety of Stimulus Parameters — 2.13 milliamps
Phase 2 N=15 Technology That Permits Focal Dose of Antibiotics to be Delivered to Lower Limb(s) of Diabetic Patients
Diabetes · Infection
Primary: Efficacy of Timentin Delivered by PILP Procedure (Treatment Group) Versus Intravenous Delivery (Control Group) at Reducing Microbiological Load in Subjects With…
Phase 2 N=175 Preventing Diabetic Foot Ulcers Through Cleaner Feet
Diabetic Foot Ulcer
Primary: Time to New Foot Complication Among All Randomized Participants — 12; 14 Participants
Phase 4 N=840 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Peripheral Arterial Occlusive Disease
Primary: Complete Healing of Ischemic Necroses and Ulcerations at 12 Weeks After the End of Study Drug Treatment — 49; 43; 27; 30 participants — p=0.2587
N/A N=182 Less Infections for the Diabetic Foot
Diabetic Foot
Primary: Number of Participants Experiencing Clinical Failure — 26; 30 Participants
N/A N=30 Investigating Outcomes of Lower Limb Trauma
Trauma
Primary: Functional Outcome (Consisting of Questionnaire Score, Hamlyn Mobility Score (HMS) Gait/Activities of Daily Living Parameters) — 19.7; 58.2 units on a scale
N/A N=38 Collaborative-care Rehabilitation After Dysvascular Amputation
Diabetes Complications · Peripheral Arterial Disease
Primary: Timed Up-and-Go Test — 19.4; 20.7; 18.2; 18.8 seconds — p=0.87