N/A N=39 Characterization of Placebo Responses in Stable Asthma
Asthma Placebo Effects
Primary: Change in FEV1 — 20.1; 7.5; 7.3; 7.1 percentage change in FEV1
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=139 Antidepressant Treatment at an Inner City Asthma Clinic
Depression · Asthma
Primary: Asthma Control Questionnaire (ACQ) — 1.15; 1.63; 1.39; 1.23 units on a scale
N/A N=14 Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway
Asthma
Primary: Maximum Change From Baseline in Airway Blood Flow (Qaw) — -11.0; 14.1; 23.9; 25.5 change from baseline ( µl/min/ml) — p=< 0.001
N/A N=233 Asthma Symptom Management Through Mindfulness Training
Asthma
Primary: Change From Baseline in Asthma Control at 18 Months — 1.27; 1.17 score on a scale
Early Phase 1 N=34 Ginger's Therapeutic Potential in Asthma
Asthma
Primary: Change in Tolerance to Inhaled Methacholine — 5.3; 24.2 mg/ml
Phase 4 N=259 Study of the Ease of Use and Correct Use of Placebo ELLIPTA® Inhaler in Subjects With Asthma
Asthma
Primary: The Percentage of Participants With Asthma Who Rated the Use of the ELLIPTA Inhaler as Easy or Very Easy, Among Those Who Demonstrated Correct Use of the Inhaler at the…
Phase 3 N=47 Montelukast Compared With Placebo and Salmeterol in Exercise-Induced Bronchoconstriction (0476-316)
Asthma, Exercise-Induced
Primary: Maximum Percent Fall in Forced Expiratory Volume in 1 Second (FEV1) After Exercise Challenge at 2 Hours Post-dose in Patients With Exercise-Induced Bronchoconstriction…
N/A N=22 Acute Effect of Mometasone on Beta-adrenergic Airway and Airway Vascular Relaxation in Severe Asthma
Asthma
Primary: Albuterol-induced Change in FEV1 — 0.27; 0.18; 0.32; 0.20 liters
N/A N=21 Positive Airway Pressure for the Treatment of Asthma
Asthma · Sleep Apnea
Primary: Asthma Control Test — 19.3; 19.8; 19.1; 19.6 units on a scale — p=0.8
N/A N=64 Effects of Open-label Placebos on COVID-related Psychological Health
Stress · Anxiety · Depression
Primary: COVID-19 Related Stress — 34.93; 35.13; 26.24; 32.37 score on a scale
Phase 2 N=35 Inhalation of Corticosteroids in Smoking and Non-smoking Asthmatics.
Asthma
Primary: Late Asthmatic Response (LAR) - Smokers: Absolute Change From Saline in Minimum Forced Expiratory Volume in One Second (FEV1) Between 4-10 Hours (Hrs) After Allergen…
Phase 2 N=18 PEEP as Rescue Therapy for Asthmatics With Elevated BMI
Asthma
Primary: Central and Peripheral Elastance — 391; 461; 587; 334 cmH2O/L
Phase 3 N=78 Study in Adult Patients With Moderate to Severe Asthma
Asthma
Primary: Change From Baseline in Average VAS Score Perceptions of Asthma - Over the Entire 14-day Treatment Period - Question #3 — 2.68; 1.63 score on a scale — p=0.385
N/A N=81 Fenzian Asthma Multicenter Outcomes Study
Asthma
Primary: Change in Asthma Control Questionnaire (ACQ) 7 Score — -0.35; -0.29 ACQ7 score
N/A N=530 School-based Asthma Therapy: Stage 2 Effectiveness Study
Asthma
Primary: Number of Symptom Free Days — 10.7; 11.6 Days
Phase 3 N=158 A 12-week Study to Compare the Efficacy and Safety of Albuterol Spiromax® Versus a Placebo in People 12 Years and Older With Persistent Asthma
Asthma
Primary: Baseline-adjusted Forced Expiratory Volume in 1 Second (FEV1) Area Under the Curve (AUC 0-6) Over the 12-week Treatment Period — 0.28; 1.11 L*hr — p=<0.0001
Phase 2 N=8 A Double Masked, Placebo Controlled, Single Center, Randomized Clinical Trial to Assess the Safety and Efficacy of Subjects With Mild Asthma Induced by the Bronchial Allergen Challenge (BAC)
Atopic Asthma
Primary: Number of Subjects With Serious Adverse Events — 0; 0 participants
N/A N=26 The Effect of Montelukast on Asthma Control in Overweight/Obese Atopic Asthmatics
Asthma · Obesity · Inflammation
Primary: Asthma Control Test (ACT) Scores — 25.00; 20.5; 24.00; 15.75 units on a scale
Phase 4 N=105 The Effects of Montelukast on Smokers With Asthma
Asthmatic Smokers · Non-asthmatic Smokers
Primary: Sputum Neutrophil Percentages — 86.00; 72.53; 89.33; 79.84 percentage of neutrophils
N/A N=13 Dietary Supplementation With Soy Isoflavones in Asthma
Asthma
Primary: Exhaled Nitric Oxide — 67.0; 54.8 parts per billion (ppb) — p=<0.03
Phase 2 N=20 Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma
Asthma
Primary: Number of Asthma Exacerbations in Three Months — 30; 31 exacerbations
Phase 2 N=21 The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Asthma · Bronchial Hyperresponsiveness
Primary: Adenosine Challenge Test — 18.46; 142.61 mg/ml
Phase 2 N=155 Environmental Control as Add-on Therapy in Childhood Asthma
Asthma
Primary: The Medication Treatment Step Assigned — 4.03; 4.05 score on a scale
Phase 2 N=24 Effect of Inhaled TD-8236 on Allergen-induced Asthmatic Response
Asthma
Primary: Area Under the Curve of Change From Baseline in Forced Expiratory Volume (in 1 Second) (FEV1) From 3 to 8 Hours After Inhaled Allergen Challenge at Day 14 — -0.53…
Phase 2 N=15 A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma
Severe, Refractory Asthma · Airway Inflammation · Airflow Obstruction
Primary: 16 Weeks - Juniper Asthma Quality of Life Questionnaire (AQLQ) Score — 4.7; 4.6 units on a scale
Early Phase 1 N=39 Defining and Treating Depression-related Asthma
Asthma · Depression · Childhood Asthma
Primary: FEV1 Percent Change Post-ipratropium — 10.8 percent change — p=0.032
N/A N=68 Heart Rate Variability Biofeedback: It's Role in Asthma Therapeutics
Asthma
Primary: Magnitude Change of Airway Reactivity Measured by Methacholine PC20FEV1 — 2.9782; 2.1181 mg/ml — p=>0.1
N/A N=51 Effects of Whole Sprouts on Airway Allergic Inflammation
Allergic Rhinitis · Asthma · Allergy
Primary: Exhaled Nitric Oxide Concentrations — 22; 19 ppb
Phase 4 N=20 Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes
Bronchospasm, Exercise-Induced
Primary: Spirometry and Specific Airway Conductance Measured by Body Plethysmography Before and After Exercise Challenge After Randomized Administration of Either Inhaled…
Phase 3 N=64 A Study to Investigate the Effects of PT027 (Budesonide/Albuterol Sulfate) Metered-dose Inhaler Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With Asthma
Asthma, Exercise-Induced
Primary: Maximum Percentage Fall From Post-dose, Pre-exercise Baseline in Forced Expiratory Volume in 1 Second (FEV₁) Observed up to 60 Minutes Post-exercise Challenge — 6.95…