Clinical Trial Search

Primary: Number of Participants With Greater Than or Equal to 50% Reduction in Depression Scores, With a Mania Score Less Than or Equal to 10 — 4; 3; 10; 8 participants

Primary: Depressive Relapse — 3; 4 Participants

Primary: Remission — 16; 13 Participants — p=<0.0001

Primary: Montgomery-Asberg Depression Rating Scale (MADRS) Change Scores — -15.7; -13.8; -16.0; -15.5 score on a scale — p=.59

Primary: Montgomery Asberg Depression Rating Scale (MADRS) (Montogomery and Asberg, 1979) — 26.20; 20.20; 16.11; 15.22 units on a scale — p=0.05

Primary: The Primary Efficacy Endpoint is the Comparison of Baseline and Week 8 Endpoint in the 17-item HAM-D Total Scores — 23.1; 10.57 Scores on a scale — p=<0.0001

Primary: Percentage of Participants With >=50% Improvement From Baseline in Clinical Global Impression for Bipolar Disorders Overall Severity — 37; 21 percentage of participants

Primary: Assessment of Change in Depressive Symptoms From Baseline on the Montgomery Asberg Depression Rating Scale (MADRS) — -15.5 units on a scale — p=<.01

Primary: Change From Baseline in Mean Beck Depression Inventory (BDI) Score at Week 2 — -13.01; -3.76 units on a scale — p=0.016

Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -9.64; -5.32 units on a scale

Primary: Measure of Response by Change From Baseline to End of Study in BISS Depression and Mania Scale Scores — 35.7; 61.8; 25; 48 percentage change in score on BISS scale…

Primary: Reductions Over Time in Anxiety Symptoms as Measured by Hamilton Anxiety Rating Scale — 14; 18.81; 11.78; 17.70 Units on scale — p=.02

Primary: Change in the Inventory of Depressive Symptomatology-Clinician Rated (IDS-CR) Score — -16.5 units on a scale

Primary: Mean Montgomery-Åsberg Depression Rating Scale (MADRS) Score at Baseline for Both Groups, and After 12 Weeks of Lamotrigine Monotherapy for the Bipolar Group — 27.79…

Primary: Brain Activity (Beta Power) in Left vLPFC — -88.78; 1437.64; 13.43; -128.00 Percentage of change post versus pre — p=0.29389090

Primary: HAM-D 17 Item: Hamilton Depression Rating Scale — 6.6; 4.91; 2.333; 3.75 score on a scale

Primary: The Montgomery-Asberg Depression Rating Scale (MADRS) — 31.95; 9.95; 10.95 score on a scale — p=<.001

Primary: Mania Rating Scale — 4.54; 5.57 units on a scale

Primary: Time to Intervention for Any Mood Episode (TIME) — NA; NA Days — p==0.438

Primary: Part A: Number of Participants With at Least One Treatment-Emergent Adverse Events (TEAEs) — 16 Participants

Primary: K SADS-Present Version (KSADS-P) — 0; 2; 1; 0 participants

Primary: Response to Treatment — 21; 9; 6; 11 Participants — p=.02

Primary: Change From Baseline to Day 43 in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score — -18.9; -20.7; -19.7 score on a scale — p=0.514

Primary: Number of Patients Whose Mood Improved According to MADRS and YMRS Scale Scores. — 4; 4; 4; 4 participants

Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Score — 16.9 score on a scale

Primary: Montgomery-Asberg Depression Rating Scale — -39.24 Percent change in MADRS from baseline

Primary: Change From Baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score — -16.2; -16.9; -14.5 score on a scale — p=0.021

Primary: Number of Participants With Relapse of Major Depressive Episode Within 1 Year — 4; 5 Participants

Primary: Change in Vigilance Assessed by the Melbourne Decision Making Questionnaire (MDMQ) — .176 units on a scale

Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…