N/A N=28 Comparison Between Two Treatments for Burning Mouth
Burning Mouth Syndrome
Primary: Painful Symptoms — 7.58; 6.92; 5.08; 5.33 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=100 Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
Xerostomia
Primary: Mean Response to the Question 1 'Relieving the Discomfort of Dry Mouth' in Product Performance and Attributes Questionnaire 3 (PPAQ3) at 120 Minutes(Mins) Post Treatment…
N/A N=66 Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
KERATOCONJUNCTIVITIS SICCA · XEROSTOMIA · SICCA SYNDROME
Primary: The Xerostomia Inventory — 40.2; 39.3 units on a scale — p=0.05
N/A N=129 Blinded Dry Mouth Spray Crossover Study
Xerostomia · Head and Neck Cancer · Xerostomia Following Radiotherapy
Primary: Oral Dryness — 45.5; 46.6; 52.76; 54.1 units on a scale — p=<0.501
N/A N=137 Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control
Dry Mouth
Primary: Response to "Relieving the Discomfort of Dry Mouth" From the Modified PPAQ I 4- and 6-hours Post-use on Day 1 of Treatment — 2.51; 3.26; 3.43 score on a scale
Phase 2 N=50 Herbal Mouthrinse for Oral Mucositis Study
Oral Mucositis
Primary: Maximum Change in Mean Mouth and Throat Soreness (MTS) Score From Baseline Through Weeks of Radiation Therapy Using the MTS Question of the Modified Oral Mucositis Daily…
Phase 4 N=100 Effect of Korean Red Ginseng (KRG) on Dry Mouth
Xerostomia
Primary: Visual Analogue Scale of Subjective Dry Mouth — 5.21; 5.03 cm — p=<0.05
N/A N=39 Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia
Primary: Change in Dry Mouth Symptom by Visual Analog Scale at 14 Days From Baseline — 10.1; 11.6; 13.0 mm
N/A N=55 Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
Xerostomia
Primary: Number of Participants With Response to Post-Product Use Questionnaires 1 (PPUQ 1); Question No.1 — 1; 1; 5; 0 Participants
Phase 3 N=185 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
Xerostomia · Depression · Hypertension
Primary: Dry Mouth Questionnaire (DMQ) — 3.4; 1.4 units on a scale
Phase 2 N=60 Green Tea Lozenges for the Management of Dry Mouth
Xerostomia · Sjogren Syndrome · Dry Mouth
Primary: Change in Salivary Flow From Baseline — 0.17; 0.10; 0.66; 0.04 ml/min
N/A N=42 Clinical Evaluation of MucoPEG™ for Xerostomia
Dry Mouth · Xerostomia
Primary: Change in VAS for Mouth Dryness — -0.8; -0.7; -1.5; -0.4 score on a scale — p=<0.01
Phase 2 N=104 Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome
Xerostomia · Sjogren's Syndrome
Primary: Overall Improvement Rate in Dry Mouth Symptoms — 26.0; 20.0; 44.0; 27.1 percentage of participants
Phase 3 N=58 Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders
Temporomandibular Disorders
Primary: Pain Intensity (German Pain Questionnaire; Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)) — 5.40; 5.53; 3.90; 3.89 units on a scale
N/A N=9 Transcranial Magnetic Stimulation for Facial Pain
Trigeminal Nerve Injuries · Post-herpetic Neuralgia · Facial Pain
Primary: Visual Analogue Scale (VAS) — 5.4 score on a scale
N/A N=25 Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population
Xerostomia
Primary: Subjective Perception of Mouth Dryness — 6.92; 6.46; 4.21; 3.46 units on a scale — p=.45
N/A N=16 Effects of an External Oral Irrigation Device on Patients With Dry Mouth
Xerostomia
Primary: Change in Oral Health Related Quality of Life (OHRQoL) — 10.2 score on a scale
Phase 2 N=86 Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast Cancer
Advanced Breast Cancer
Primary: Number of Participants With Stomatitis Grade ≥ 2 — 2; 83; 1 Participants — p=<0.001
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
Phase 3 N=196 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer
Head and Neck Cancer · Xerostomia
Primary: Phase II: Treatment Compliance (Number of Compliant Patients) — 12; 44 Participants
N/A N=29 Duration of Effect of Biotene Spray in Patients With Dry Mouth
Dry Mouth
Primary: Mean Duration of Action of Intervention — 27; 26 minutes
Phase 2 N=60 MOM's PAIN (Methylene Blue for Oral Mucositis' PAIN)
Malignant Neoplasm · Oral Pain · Stomatitis
Primary: Change in Pain Scores Assessed Within the Numeric Rating Scale (NRS) Component of the Modified Harris Mucositis-related Pain Assessment Tool — 1.69; 5.2; 4.54; 5.15…
N/A N=80 Oral Irritation Study of Two Experimental Mouthrinses
Oral Manifestations
Primary: Percentage of Participants With an Abnormal Condition by Anatomical Site at Screening — 0; 0; 0; 0 Percentage of Participants
Phase 1 N=20 Fluoride Retention in the Mouth of Older Adults
Hyposalivation
Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412
Phase 2 N=37 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis
Aphthous Stomatitis
Primary: Effect of Ibuprofen, Diphenhydramine and Aluminium MgS Measured on Decrease in Pain Level and Burning Sensation — 3.176; 3.821 scores in Visual Analogue Scale
Phase 2 N=20 Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients
Head and Neck Squamous Cell Carcinoma
Primary: The Number of Subjects Who Achieve at Least a 30 Percent Decrease in Pain From Baseline in VAS Pain Score Calculated From BPI Questionnaire. — 8 Participants
Phase 1 N=100 Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations
Safety Issues
Primary: OMI-20 Total Score Change From Baseline to Day 3 — 0.0; 0.0 score on a scale
N/A N=60 The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients
Microstomia · Systemic Sclerosis
Primary: Change From Baseline in Oral Aperture Measurement — 32.98; 32.92; 33.40; 34.37 milimeters — p=0.564
Phase 2 N=59 Study of the Effects of Brilacidin Oral Rinse on Radiation-induced Oral Mucositis in Patients With Head and Neck Cancer
Head and Neck Neoplasms · Mucositis
Primary: Incidence of Severe OM During Radiation Therapy in Subjects Receiving a Cumulative IMRT Dose of at Least 55 Gy — 15; 9; 10; 12 Participants
Phase 1 N=48 The Effect of Palatal Brushing on Denture Stomatitis
Denture Stomatitis
Primary: Palatal Inflammation — 3; 3; 2.5; 2 units on a scale — p=<0.0001