Phase 2 N=240 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
CRPS
Primary: Epidural Medication Consumption Rate — 6.40; 5.77 mL/h — p=0.003
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 Transcranial Magnetic Stimulation (TMS) for CRPS
Complex Regional Pain Syndrome (CRPS)
Primary: Present Pain Intensity — 6.5; 6.3; 3.1; 3.7 Units on a scale
N/A N=4 TMS for CRPS - Pilot Study
Complex Regional Pain Syndrome (CRPS)
Primary: Change in Pain — 5.2; 0.7 units on a scale
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
N/A N=22 Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
Reflex Sympathetic Dystrophy
Primary: Pain Severity — 22.18; 23.36; 18.00; 23.82 units on a scale — p=0.065
N/A N=66 "Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Complex Regional Pain Syndrome I of Lower Limb
Primary: Number of Participants Operated for Complex Regional Pain Syndrome Who Had Transposition of Anterior Tibial Tuberosity — 1; 0; 2 participants
Phase 2 N=24 Study of TAK-935 as an Adjunctive Therapy in Adult Participants With Complex Regional Pain Syndrome (CRPS)
Complex Regional Pain Syndrome
Primary: Change From Baseline in Mean 24-Hour Pain Intensity as Assessed by NPS Score to the End of Part A — -0.74; -1.05 scores on scale
Phase 3 N=318 Safety of Intravenous Neridronic Acid in CRPS
Complex Regional Pain Syndrome
Primary: Number of Participants With Occurrence of Any Treatment Emergent Adverse Event (TEAE) — 277; 27; 275; 267 Participants
N/A N=36 Virtual Reality Guided Imagery for Chronic Pain
Complex Regional Pain Syndromes · Back Pain
Primary: Number of Participants Who Are Recruited But Not Enrolled as Documented in Participant Log — 60 Participants
Phase 2 N=22 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain.
Neuralgia
Primary: Pain on the Visual Analog Scale (VAS) — 6.4; 4.0 units on a scale
N/A N=152 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
Chronic Lower Limb Pain
Primary: Primary Composite Endpoint - Treatment Success — 81.2; 55.7 percentage of subjects — p=<0.0001
Phase 3 N=44 Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome
Complex Regional Pain Syndrome
Primary: Pain Score — 5.9; 6.0; 6.5; 6.8 score on a scale — p=0.19
N/A N=15 Spinal Cord Stimulation for Restless Legs Syndrome
Restless Legs Syndrome · Neuropathic Pain
Primary: Percent Change MSNA Burst Frequency From Baseline to 60 Minutes — -29; -24 Percent change MSNA burst frequency
Phase 2 N=132 Topiramate for Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome (CSPN)
Cryptogenic Sensory Peripheral Neuropathy in Metabolic Syndrome
Primary: Intraepidermal Nerve Fiber Density (IENFD) — -0.6064; -0.396 fibers/mm/year (52 weeks)
N/A N=64 Remote Ischemic PreConditioning Effect on Postsurgical Pain
Pain
Primary: Comparison of Pain Intensity and Unpleasantness Postoperatively — 4.82; 4.83; 4.05; 4.81 units on a scale
N/A N=129 Evaluation of CRB in PROM Patients
Premature Rupture of Fetal Membranes
Primary: Time of Labor — 850.4; 1016.6 Minutes
Phase 2 N=18 Crizanlizumab for Treatment of Retinal Vasculopathy With Cerebral Leukoencephalopathy (RVCL)
RVCL - Retinal Vasculopathy Cerebral Leukoencephalopathy
Primary: Change in the Percentage of White Matter Hyperintensity (WMH) Lesion Volume on FLAIR MRI in RVCL Patients — 31.3 Percent (%)
N/A N=8 C-RFA of Residual Limb Neuroma
Phantom Limb Pain · Neuroma Amputation
Primary: Numeric Rating Scale (NRS) for Pain at 6 Months — 4 Participants
N/A N=31 Assess the Effectiveness of Pulse RadioFrequency in Patients With Chronic Lumbar Radicular Pain
Chronic Pain · Back Pain
Primary: Recruitment Rate — 32 Participants
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale
Phase 3 N=47 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)
Familial Cold Autoinflammatory Syndrome (FCAS) · Familial Cold Urticaria · Muckle-Wells Syndrome (MWS)
Primary: Change From Baseline to Week-6 (Part A) Endpoint in Mean Key Symptom Score (KSS) — 2.4; 3.1; 2.1; 0.5 Units of a Scale — p=<.0001
Phase 2 N=131 A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Diabetic Peripheral Neuropathic Pain (NP05).
Diabetic Peripheral Neuropathic Pain
Primary: Change From Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) — -1.70; -1.81 score on a scale
Phase 2 N=59 A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RA
Rheumatoid Arthritis
Primary: Change in CRP From Baseline to Day 42 — -16.12; 9.60 percentage change from baseline
Phase 4 N=280 Pain Response Evaluation of a Combined Intervention to Cope Effectively
Chronic Pain
Primary: Brief Pain Inventory (BPI) Total Pain Severity — 6.1; 5.7; 5.8 score on a scale
Phase 4 N=32 GRASSP: Gralise® for Spine Surgery Pain
Post-laminectomy Pain Syndrome
Primary: Mean Change in Numeric Rating Scale (NRS) — -0.56; -0.54 units on a scale
Phase 2 N=125 Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Diabetic Peripheral Neuropathic Pain
Diabetic Peripheral Neuropathic Pain
Primary: Change From Baseline in Average Pain Intensity as Measured by the NRS — -1.98; -1.56 score on a scale
N/A N=133 Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Restless Legs Syndrome
Primary: Number of Subjects for Which the Clinician Reported "Much Improved" or "Very Much Improved" on the Clinical Global Impressions-Improvement (CGI-I) Scale for TOMAC…
Phase 4 N=220 Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain
Central Neuropathic Pain
Primary: Mean Pain Score at Endpoint as Measured by Daily Pain Rating Scale (DPRS) — 4.8; 5.0 scores on scale — p=0.578
N/A N=20 Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction
Restless Legs Syndrome
Primary: Percentage of Subjects Without a Clinically Significant Increase in RLS Symptoms During the First Phase Involving an Opioid Dose Reduction of >= 20% Relative to…
N/A N=575 Persistent Pain After CS Delivery
Persistent Pain After Delivery
Primary: Persistent Pain-PERCEIVED STRESS Scores Stratified by the Rate of Recovery — 11.4; 12.9; 15.4 units on a scale — p=<0.01