Clinical Trial Search

Primary: The Cleanliness of the Prep as Measured by the Ottawa Scale — 6.3; 6.8; 6.9; 5.1 Ottawa Scale

Primary: Intestinal Transit Time — 42.3; 15.66 hours — p=<0.001

Primary: Percentage Subjects With Post Procedure Cleansing Level as Measured by the Boston Bowel Preparation Scale (BBPS) Adequate Cleansing-(BBPS>1 ) — 88.9 percentage of…

Primary: Incidence of Known Adverse Drug Reactions (ADRs) — 2; 1; 2; 6 Participants

Primary: Change in Methane Production — 10645; 14635 parts per million*minutes

Primary: The Quality of the Colon Preparation Will be Graded Using the Boston Bowel Preparation Scale — 7.86; 8.05; 7.99 units on a scale

Primary: Time to Complete Meconium Evacuation in Days — 7; 8 days of life — p=0.61

Primary: Colonic Geometric Center at 24 Hours (GC24) — 3.1; 3.5; 2.2 units on a scale

Primary: Bowel Movement (BM) Within 3 Days of Surgery — 29; 32 Participants — p=0.41

Primary: Difference (After Treatment Minus Before Treatment) of EGFR Expression — 0.17; -0.40; 0.21 ng/ml

Primary: Endoscopist Evaluation of Colon Cleanliness in the Lubiprostone Group vs the Placebo Group — 1.38; 1.24 score on a scale — p=0.05

Primary: Efficacy of Large Bowel Cleansing as Assessed by the Physician Performing the Colonoscopy — 18.69; 20.1 Score

Primary: Number of Participants With Boston Bowel Preparation Scale( BBPS) >1 in All Colon Segments After the Use of MCS — 9 Participants

Primary: The Number of High-Amplitude Propagating Contractions (HAPC) — 8.7; 2.9 Number of HAPC with amplitude ≥100mmHg — p=0.012

Primary: Fecal Soiling - Number of Participants That Gained and Maintained Continence on Each Flushing Regimen — 1; 4 Participants

Primary: The Overall Cleanliness of the Prep as Measured by the Ottawa Scale — 4.8; 6.2 Ottawa Score

Primary: Efficacy: Percentage of Patients With Successful Preparations Based on a 4 Point Scale — 77.6; 80.1 percent of participants — p=0.005

Primary: Efficacy of Bisacodyl and Lactulose as a Preparation for Colonoscopy. — 5.7; 7.4; 7.8 units on a scale

Primary: Change From Baseline in Colonic Transit Time (CTT) — -727; -15; 366 minutes

Primary: Percentage of Participants With Successful Bowel Movement (BM) Within 24 Hours of PEG + E Administration — 19.2; 31.4; 19.2 percentage of participants — p=0.1790

Primary: Complete Small Bowel Transit — 75; 95 percentage of subjects with passage

Primary: Number of Spontaneous Bowel Movements (SBMs) Within 1 Week — 4.6; 4.0 number of SBMs — p=0.1290

Primary: Percentage of Subjects Classified as a Responder Defined by "Excellent" or "Good" — 87.7; 81.5 Percentage of participants — p=0.0067

Primary: Colonic Transit at 24 Hours — 2.68; 3.12; 1.93 units on a scale — p=0.059

Primary: Number of Participants With an Improvement of 1 or More in HE Grade at 24 Hours — 21; 13 participants

Primary: Number of Patients With Successful Bowel Cleansing (Overall Colon) — 135; 155; 116; 95 Participants — p=0.038

Primary: Percentage of Subjects With Successful Overall Colon Preparation, Assessed With the Cleansing Score (4-point Scale) — 71.42; 79.03 adjusted percentage of subjects…

Primary: Complete Spontaneous Bowel Movement (CSBM) Overall Responder — 46; 42; 7 participants — p=<0.0001

Primary: Quality of Bowel Preparation — 3.4; 2.5; 3.6; 7.4 units on a scale

Primary: Change in Patient Assessment of Constipation (PAC) - Symptoms (Sym) — -0.22; -0.29 units on a scale — p=<0.05