Phase 4 N=77,664 Community Health Azithromycin Trial in Burkina Faso
Childhood Mortality
Primary: All-cause Mortality Rate in Children Aged 1-59 Months — 8.2; 10.0 deaths per 1000 person years
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Phase 4 N=190,238 Mortality Reduction After Oral Azithromycin: Mortality Study
Childhood Mortality
Primary: All-cause Mortality Rate in Children Aged 1-60 Months — 14.6; 16.5 deaths per 1000 person-years
Phase 4 N=21,832 Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso
Childhood Mortality
Primary: 6 Month Mortality - All Cause — 42; 50 Participants
Phase 4 N=864,493 Azithromycin for Child Survival in Niger: Mortality and Resistance Trial
Mortality · Resistance Bacterial · Child, Only
Primary: All-cause Mortality (1-59 Months Old) — 13.8; 11.9; 13.9 deaths per 1,000 person-years
Phase 4 N=66,228 Mortality Reduction After Oral Azithromycin Contingency: Mortality Study
Childhood Mortality
Primary: All-cause Mortality Rate in Children Aged 1-60 Months — 24.8; 26.7 deaths per 1000 person years
Phase 4 N=449 Gut and Azithromycin Mechanisms in Infants and Children II
Malaria
Primary: Malaria Status — 18; 16 Participants
Phase 4 N=450 MORDOR II Burkina Faso: Longitudinal Trial
Child Growth · Diversity of Microbiome · Child Mortality
Primary: Intestinal Microbial Diversity — 46.3; 49.5 index score
N/A N=398 Reducing Asthma Morbidity In High Risk Minority Preschool Children
Asthma
Primary: Asthma Control as Determined by Test for Respiratory and Asthma Control in Kids Assessment Tool — 70; 75; 85; 80 score on a scale
N/A N=167 Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment
Burkitt Lymphoma · Retinoblastoma · Diffuse Large B-cell Lymphoma
Primary: Protocol Compliance as Measured by Percent Compliance to Prescribed Chemotherapy — 73.8; 96.0; 50.0; 74.9 percentage of compliance — p=<0.001
N/A N=347 Communicating Health Information and Improving Coordination With Primary Care
Hypertension · Dyslipidemias · Diabetes
Primary: Undertreatment of Hypertension (>=140/90 mmHg), Dyslipidemia (LDL >=160 mg/dL or Triglyceride >=150 mg/dL), and/or Glucose Intolerance (if Prediabetes, Hemoglobin A1c…
Phase 3 N=59,721 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh
Vitamin A Deficiency · Maternal Mortality · Infant Mortality
Primary: All-cause, Pregnancy-related Mortality — 41; 47; 50 Participants — p=0.05
Phase 3 N=579 Chemopreventive Therapy for Malaria in Ugandan Children
Malaria
Primary: Incident Malaria Cases Per Person Year at Risk in HIV-unexposed Participants — 6.95; 6.73; 5.21; 3.02 Episode per person year at risk — p=0.57
N/A N=2,288 Alive & Thrive Evaluation in Burkina Faso
Breast Feeding · Breast Feeding, Exclusive
Primary: Exclusive Breastfeeding on the Day Preceding the Interview as Assessed by Cross Sectional Survey — 0.933; 0.512 percentage of exclusive breastfeeding
N/A N=2,221 Kangaroo Mother Care Before Stabilisation Amongst Low Birth Weight Neonates in Africa
Kangaroo Mother Care · Preterm Infant · Death; Neonatal
Primary: Mortality Within 7 Days — 81; 83 Participants
Phase 3 N=44,567 Antenatal Micronutrient Supplementation and Infant Survival
Infant Mortality · Preterm Birth · Low Birth Weight
Primary: Infant Mortality Through 6 mo of Age — 764; 741 participants — p=0.36
N/A N=14,490 Smart Discharges for Mom & Baby
Maternal Sepsis · Neonatal Sepsis
Primary: Post-discharge Readmission or Mortality — 231; 349 Participants
Phase 3 N=396 Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea
Diarrhea · Cholera
Primary: Stool Output — 4769; 4742; 1688; 1704 gram — p=0.9941
N/A N=103,117 Trial of the Use of Antenatal Corticosteroids in Developing Countries
Preterm Birth
Primary: Neonatal Mortality Rate at 28 Days in <5th Percentile Birth Weight Infants (as a Proxy Measure for Prematurity) — 566; 524 Participants — p=0.65
N/A N=500 Reducing Post-Hospital Mortality in HIV-infected Adults in Tanzania
HIV Infections
Primary: Number of Participant Deaths in the First 12 Months Post-hospitalization — 43; 42 Participants — p=0.91
N/A N=59 Improving Parent-Child Interactions to Enhance Child Health
Child Obesity
Primary: Change in Child Body Mass Index (BMI) Percentile — 3.66; 1.74; 1.12; 0.88 percentile — p=.73
N/A N=5,020 Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
Neonatal Death · Perinatal Death · Depression
Primary: Neonatal Mortality — 46; 37 Participants — p=0.314
Phase 2 N=132 Management of Severe Acute Malnutrition in SCD, in Northern Nigeria
Sickle Cell Anemia · Severe Acute Malnutrition
Primary: Enrollment Rate at the End of the 6-month Recruitment Period — 111; 22; 110; 22 participants
Phase 2 N=354 Praziquantel in Children Under Age 4
Schistosomiasis · Schistosomiasis Mansoni · Schistosoma Japonicum Infection
Primary: Treatment Efficacy — 96; 98; 96; 98 percentage change
N/A N=40 Childhood Risk Reduction Program in Hispanics
Breast Feeding, Exclusive
Primary: Exclusive Breastfeeding (EBF) — 9; 4; 11; 13 Participants
N/A N=420 Causes of Rotavirus Vaccine Failure in Zambian Children
Diarrhoea
Primary: Proportion of Immunized Infants Exposed to High Breast Milk Anti-rotavirus Immunoglobulin-A Who Fail to Seroconvert — 0.602 Proportion of exposed infants
N/A N=5,392 Impact of Body Weight on the Immediate Health of the Pediatric Population
Childhood Obesity
Primary: Diagnosis of Infectious Disease — 900; 1067 Participants — p=.026
N/A N=18,693 Paediatric Rapid Sepsis Trigger (PRST) Tool
Sepsis · Infection
Primary: Time to Administration of an Appropriate Antimicrobial — 115; 123; 239; 261 minutes
N/A N=170 Verbal Autopsy of Maternal Deaths, Stillbirths, and Neonatal Deaths in BetterBirth
Perinatal Death · Neonatal Death · Stillbirth
Primary: Cause of Death — 20; 35; 56; 50 Participants
N/A N=412 mHealth-Assisted Conditional Cash Transfers to Improve Timeliness of Vaccinations (D0271)
Immunization
Primary: Number of Timely Vaccinations Received — 10; 5; 5; 9 Participants
N/A N=47 Healthy Bodies, Healthy Kids
Child Mental Disorders · Obesity · Metabolic Syndrome
Primary: DEXA-measured Adiposity — 0.76; -0.43; -2.79 kilograms — p=0.01