N/A N=40 Clinical Outcomes Study Using a New Implantable Neurostimulation System for Chronic Intractable Pain
Chronic Pain
Primary: Proportion of Subjects Satisfied With Treatment at 90 Days Post-IPG Implantation — 32 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=125 Evaluate St Jude Medical Prodigy Neuromodulation for FBSS or Chronic Pain of the Trunk and/or Limbs
Chronic Pain
Primary: Percentage Change From Baseline in Overall VAS at 3 Months — -51.3 Percentage change
N/A N=331 PROs in Chronic Low Back Pain Patients With Accompanying Lower Limb Pain (Neuropathic Component) Treated With Pregabalin
Low-Back Pain
Primary: Change From Baseline in Pain Related Sleep Interference Scale (PRSIS - Past Week Recall) — 3.1; 2.9; -1.306; -0.357 scores on a scale — p=<0.001
N/A N=231 ECAP-controlled, Closed-loop Stimulation to Treat Chronic Trunk and/or Limb Pain (ECAP)
Chronic Pain · Back Pain · Pain
Primary: Evoked Compound Action Potentials (ECAPs) as Measured by the Evoke SCS System — 1.3 ratio
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=10 Ultra-high Frequency (500 KHz) Spinal Cord Stimulation for Treatment of Chronic Back Pain or Lower Limb Pain
Pain, Chronic · Pain, Back · Pain, Radiating
Primary: Change in Visual Analog Score From Baseline to Day 14 — -5.1 score on a scale
N/A N=152 A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
Chronic Lower Limb Pain
Primary: Primary Composite Endpoint - Treatment Success — 81.2; 55.7 percentage of subjects — p=<0.0001
Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
Phase 4 N=17 Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
Pain, Intractable · Breakthrough Pain · Chronic Pain
Primary: Change From Baseline in the Numerical Rating Pain Scale (NRS) — 1.87; 1.81 units on a scale
N/A N=64 OPTIONS Spinal Cord Stimulation Programming Parameters
Pain, Intractable
Primary: Change in Average Overall Pain as Measured by the Diary-reported Numeric Pain Rating Scale (NPRS) Questionnaire — -3.7 units on a scale — p=<0.01
Phase 2 N=222 PF-06372865 In Subjects With Chronic Low Back Pain
Chronic Low Back Pain
Primary: Change From Baseline in Daily Low Back Pain Intensity (LBPI) Score as Measured by an 11-point Numeric Rating Scale (NRS) at Week 4 — -1.19; -1.03; -1.45 units on a scale
Phase 4 N=304 Spinal Cord Stimulation for Low Back Pain
Chronic Pain
Primary: Effectiveness of SCS Stimulation in Reducing Back Pain Associated With Failed Back Surgery Syndrome After 12 Months of Use.
N/A N=105 SCS Programming Study in Treating Intractable Chronic Back Pain (NOVA)
Chronic Back Pain
Primary: Percentage of Subjects Who Respond to DTM-SCS Therapy Compared to Conventional SCS Therapy — 93.5; 36.4 percentage of participants
Phase 4 N=36 Determining the Prognostic Value of Continuous Intrathecal Infusion
Lumbar Post-Laminectomy Syndrome · Chronic Low Back Pain · Vertebral Compression Fracture
Primary: Change in Numerical Rating Scale Pain Scores (NRS) With Activity — 8.40; 8.00; 4.13; 4.19 Score on a scale
N/A N=25 Study of PM Modulation Therapy in Trial Phase
Chronic Pain
Primary: Change in Pain Relative to Baseline and After a Trial Period — 4.2; 2.4 Score on a 11 point scale
N/A N=21 Transcranial Direct Current Stimulation for Chronic Low Back Pain
Chronic Low Back Pain
Primary: West Haven-Yale Multidimensional Pain Inventory (General Activity Subscale) Rating — 35.3; 48.4 score on a scale
N/A N=20 VANISH for Chronic Low Back Pain
Chronic Low-back Pain
Primary: Assessment of Opioid Use Via Subject Report — 47.5; 21.75 morphine milligram equivalent
N/A N=112 Comparison of DTM™ SCS Therapy Combined With Conventional Medical Management (CMM) to CMM Alone in the Treatment of Intractable Back Pain Subjects Without Previous History of Lumbar Spine Surgery
Pain, Intractable · Pain, Chronic
Primary: Percentage of Individual Responders — 40; 2 Participants — p=<0.0001
N/A N=21 tDCS for Chronic Low Back Pain
Chronic Low Back Pain
Primary: West Haven-Yale Multidimensional Pain Inventory (WHY-MPI) General Activity Subscale Rating — 35.3; 48.4 score on a scale — p=0.002
N/A N=70 Auricular Vagus Nerve Stimulation for Chronic Pain
Low Back Pain
Primary: Low Back Pain Intensity — 1.24; 1.73 units on a scale
Phase 2 N=40 Effect of Milnacipran in Chronic Neuropathic Low Back Pain
Low Back Pain
Primary: Effect Size of VAS Pain — 24.8; 31.3 units on a scale
N/A N=40 Effect of Peripheral Magnetic Stimulation in Patients With Chronic Lower Back Pain
Low Back Pain
Primary: Oswestry Disability Index (ODI) — 15.1; 15.0; 13.7; 4.6 Scores on a scale
Phase 2 N=153 Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain
Chronic Low-back Pain
Primary: Change From Baseline for Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) — -1.69; -1.77 score on a scale
Phase 3 N=208 Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
Chronic Pain · Low Back Pain
Primary: The Primary Endpoint is Defined as the Change of the Average Pain Intensity Score on an 11-point NRS-3 at Week 6 From Week -1 (Baseline). — -2.8 Units on a scale
Phase 2 N=149 Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Chronic Low Back Pain
Chronic Low-back Pain
Primary: Change From Baseline for Average Pain Intensity as Measured by the NRS — -1.57; -2.09 score on a scale
Phase 4 N=144 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Phantom Limb Pain
Primary: "Average" Phantom Limb Pain Intensity 4 Weeks Following Initiation of an Ambulatory Continuous Peripheral Nerve Block (as Measured by the Numeric Rating Scale Within the…
Phase 2 N=159 Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Chronic Low Back Pain
Chronic Low-back Pain
Primary: Change From Baseline for Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) at Week 4 — -1.28; -0.90 score on a scale
N/A N=770 Strategies to Assist With Management of Pain
Chronic Low Back Pain
Primary: Composite Pain Severity — 5.6; 5.6 score on a scale
Phase 4 N=343 PAIN - Postoperative Analgesia INvestigation
Postoperative Pain
Primary: Postoperative Pain as Assessed by a Numeric Pain Scale (NPS) — 5.05; 5.02 units on a scale — p=0.934
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83