N/A N=105 NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal Pain · Pain, Chronic
Primary: Short Physical Performance Battery (SPPB) — 10.95; 10.82; 11.75 score on a scale — p=0.0561
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=254 Neuromodulatory Treatments for Pain Management in TBI
Chronic Pain · Traumatic Brain Injury · Posttraumatic Stress Disorder
Primary: Change in Self-reported Pain Intensity — -1.02; -0.78; -1.03 score on a scale — p=0.2852
N/A N=70 Auricular Vagus Nerve Stimulation for Chronic Pain
Low Back Pain
Primary: Low Back Pain Intensity — 1.24; 1.73 units on a scale
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
Phase 2 N=40 Effect of Milnacipran in Chronic Neuropathic Low Back Pain
Low Back Pain
Primary: Effect Size of VAS Pain — 24.8; 31.3 units on a scale
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
Phase 2 N=131 A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Diabetic Peripheral Neuropathic Pain (NP05).
Diabetic Peripheral Neuropathic Pain
Primary: Change From Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) — -1.70; -1.81 score on a scale
N/A N=770 Strategies to Assist With Management of Pain
Chronic Low Back Pain
Primary: Composite Pain Severity — 5.6; 5.6 score on a scale
N/A N=10 Empower Opioid Misuse & Chronic Pain
Chronic Pain · Opioid Use
Primary: Pain Intensity Score Measures — 55; 57 Score on a scale
N/A N=94 Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy
Chronic Pain
Primary: Brief Pain Inventory (BPI): Number of Participants With a Pain Reduction of Greater Than or Equal to 30% — 17; 5 participants — p=0.0048
N/A N=20 Usability of a Multimodal External Neuromodulatory Device to Relieve Acute Low Back Pain
Low Back Pain · Low Back Sprain · Low Back Pain, Recurrent
Primary: Change in Pain: Visual Analog Scale (VAS) — 2.1 units on a scale (centimeters)
N/A N=114 Behavioral Treatments for Chronic Pain
Intractable Pain
Primary: Brief Pain Inventory — 4.5; 5.1 units on a scale — p=.27
Phase 2 N=125 Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Diabetic Peripheral Neuropathic Pain
Diabetic Peripheral Neuropathic Pain
Primary: Change From Baseline in Average Pain Intensity as Measured by the NRS — -1.98; -1.56 score on a scale
N/A N=106 Neuroimaging Approaches to Deconstructing Acupuncture for Chronic Pain
Fibromyalgia
Primary: Brain Neurocircuitry Underlying Chronic Pain (Percent of Time of a Somato-sensory Cortex Coactivation Pattern) — 0.1281; 0.1190; 0.1213; 0.1345 percentage of scan time…
Phase 4 N=86 Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
Chronic Pain
Primary: Pain Intensity — 11; 29 Participants
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
N/A N=14 Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
Low Back Pain
Primary: Pain — -1; -43 Percentage change from baseline to end
Phase 2 N=155 Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Diabetic Peripheral Neuropathic Pain
Diabetic Peripheral Neuropathic Pain
Primary: Change From Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) — -1.50; -1.35 score on a scale
N/A N=30 Stabilization Exercises Alone vs Stabilization Exercises Plus Neuromuscular Electrical Stimulation in People With Chronic Low Back Pain
Low Back Pain
Primary: Tolerability of Electrical Stimulation (NMES) — 0; 5; 8; 0 Participants
N/A N=20 VANISH for Chronic Low Back Pain
Chronic Low-back Pain
Primary: Assessment of Opioid Use Via Subject Report — 47.5; 21.75 morphine milligram equivalent
Phase 2 N=19 Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
Fibromyalgia · Chronic Pain · Depression
Primary: Gracely Box Intensity Rating Scale — 13.18; 14.43; 10.64; 13.00 units on a scale
N/A N=331 PROs in Chronic Low Back Pain Patients With Accompanying Lower Limb Pain (Neuropathic Component) Treated With Pregabalin
Low-Back Pain
Primary: Change From Baseline in Pain Related Sleep Interference Scale (PRSIS - Past Week Recall) — 3.1; 2.9; -1.306; -0.357 scores on a scale — p=<0.001
N/A N=47 Cognitive Behavioral Therapy for Diabetic Neuropathic Pain
Diabetic Peripheral Neuropathic Pain
Primary: Numeric Rating Scale (NRS) Pain Intensity — -0.83; -0.45 units on a scale — p=0.47
N/A N=63 Chronic Neuropathy Following Chemotherapy
Peripheral Nervous System Diseases · Chronic Pain
Primary: Chemotherapy-induced Peripheral Neuropathy — 21 participants
N/A N=21 Treatment of Insomnia Secondary to Chronic Pain
Insomnia · Pain
Primary: Insomnia Severity — 6.0; 12.8; 4.4; 13.0 units on a scale — p=0.010
Phase 2 N=153 Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Chronic Low Back Pain
Chronic Low-back Pain
Primary: Change From Baseline for Average Pain Intensity as Measured by the Numeric Rating Scale (NRS) — -1.69; -1.77 score on a scale
N/A N=21 Transcranial Direct Current Stimulation for Chronic Low Back Pain
Chronic Low Back Pain
Primary: West Haven-Yale Multidimensional Pain Inventory (General Activity Subscale) Rating — 35.3; 48.4 score on a scale
N/A N=16 Hippocampal Stimulation in Chronic Low Back Pain
Chronic Pain · Back Pain · Pain
Primary: Changes in Pain Scales — 4.6; 4.6; 4; 4.4 units on a scale