Phase 2 N=24 Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis
Chronic Rhinosinusitis (Diagnosis) · Nasal Polyps · Eosinophilia
Primary: Change in Nasal Polyp Score — .9; .3 score on a scale
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=20 Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
Chronic Sinusitis With Nasal Polyps and Eosinophilia
Primary: Ratio to Baseline in Peripheral Blood Eosinophil Counts After 6 Months of Treatment — 0.06 ratio to baseline — p=< 0.001
Phase 3 N=407 Effect of Mepolizumab in Severe Bilateral Nasal Polyps
Nasal Polyps
Primary: Change From Baseline in Total Endoscopic Nasal Polyps Score at Week 52 — 0.0; -1.0 Scores on a scale — p=<0.001
Phase 2 N=60 An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis
Nasal Polyps
Primary: Change From Baseline in Bilateral Endoscopic Nasal Polyp Score (NPS) at Week 16 — 5.67; 5.87; 5.39; 3.97 score on a scale — p=0.0009
N/A N=389 Long-term Control in Rhinosinusitis After Functional Endoscopic Sinus Surgery (FESS)
Condition of Patient 3 Years After FESS-operation
Primary: Control Status of Patients With Rhinosinusitis — 19.5; 36.8; 43.7 percentage of participants
N/A N=24 Oral Steroids in Chronic Rhinosinusitis Without Nasal Polyps
Sinusitis
Primary: Sinonasal Outcome Test (SNOT 20) — 50.33; 53.14; 37 Score out of total 100
Phase 4 N=53 Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis) · Allergic Rhinosinusitis · Chronic Eosinophilic Rhinosinusitis
Primary: Change in Sino-Nasal Outcome Test Scores (SNOT-22) — 23.18; 17.7 score on a scale
Phase 3 N=138 A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
Nasal Polyps · Chronic Rhinosinusitis
Primary: Change From Baseline in Nasal Polyp Score (NPS) at Week 24 — 0.06; -1.08 Score on a scale — p=<0.0001
Phase 3 N=127 A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
Nasal Polyps · Chronic Rhinosinusitis
Primary: Change From Baseline in Nasal Polyp Score (NPS) at Week 24 — -0.31; -0.90 Score on a scale — p=0.0140
Phase 3 N=408 Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis With Nasal Polyps
Primary: Change From Baseline in Total Nasal Polyp Score at Week 52 — -2.458; -0.380 Score — p=<.0001
Phase 2 N=27 Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis · Nasal Polyps
Primary: Objective (a) the Effect on Polypoid Mucosal Thickening in the Anterior Ethmoid and Maxillary Sinuses as Measured on Sinus CT Scan. — -8.9; 4.2 % Change
Phase 2 N=105 Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Chronic Rhinosinusitis
Primary: Change From Baseline in Nasal Polyp Score (NPS) to Week 16 — -0.87; -0.89; -0.49 score on a scale — p=0.2364
Phase 1 N=16 Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.
Chronic Rhinosinusitis (Diagnosis)
Primary: Morning "AM" Serum Cortisol Level — 17.35; 14.48 mcg/dL
N/A N=81 Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)
Chronic Rhinosinusitis · Endoscopic Sinus Surgery · Chronic Rhinosinusitis Without Polyps
Primary: Sino-nasal Outcome Test (SNOT-22) Over Time — 43.8; 42.9; 39.7; 38.5 score on a scale — p=0.819
N/A N=37 The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery
Chronic Sinusitis · Nasal Polyposis
Primary: Change in Lund-Kennedy Endoscopic Scores — -8.0; -1.5; -6.9 score on a scale
N/A N=20 Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Nasal Polyps · Gastroesophageal Reflux
Primary: Presence of Reflux in Patients With Polyposis — 15 participants
Phase 3 N=169 Efficacy and Safety of Mepolizumab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)/ Eosinophilic Chronic Rhinosinusitis (ECRS)
Nasal Polyps
Primary: Mean Change From Baseline in Total Endoscopic Nasal Polyps (NP) Score at Week 52 - ITT Population Excluding Medipharma Managed Sites — -0.62; -0.19 Scores on a Scale…
Phase 2 N=22 The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis
Rhinosinusitis
Primary: Change in Sino-nasal Outcome Test-22 Score Between Baseline and 6 Weeks, Then 6 Weeks to 12 Weeks. — 59.3; 52.9; 45.4; 51.8 units on a scale
N/A N=187 Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery
Chronic Rhinosinusitis · Endoscopic Sinus Surgery
Primary: Total Subjective Symptoms Visual Analog Scores (VAS) — 20.4; 20.7; 9.7; 8.9 score on a scale
Phase 4 N=95 Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Asthma, Aspirin-Induced · Chronic Rhinosinusitis With Nasal Polyps
Primary: Change From Baseline at Week 16 in Sinonasal Outcome Test -22 (SNOT-22) Score — -14.09; -4.37 points
Phase 2 N=105 Mepolizumab in Nasal Polyposis
Nasal Polyps
Primary: Number of Participants With a Reduced Need for Surgery at Week 25 — 16; 5; 33; 46 Participants — p=0.003
Phase 2 N=16 Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
Sinusitis · Cystic Fibrosis
Primary: Computed Tomography Evidence of Less Sinus Disease — 5.875; 3 units on a scale — p=0.2
Phase 3 N=276 Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps
Nasal Polyps
Primary: Change From Baseline in Total Endoscopic Nasal Polyps (NP) Score at Week 52 (Centrally Read) — -0.6; 0.2 Scores on a Scale — p=<0.001
N/A N=25 Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty
Rhinitis + Sinusitis, Pediatric Chronic Rhinosinusitis
Primary: Quality of Life (QoL) Outcomes Between Adenoidectomy + Maxillary Sinus Irrigation With or Without the Use of Balloon Dilation or Maxillary Sinus Ostia. — 2.48; 2.5…
Phase 3 N=223 Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps
Chronic Rhinosinusitis
Primary: Change From Baseline in Symptoms as Measured by a Composite Score for Each Symptom of Nasal Congestion, Facial Pain or Pressure Sensation, and Nasal Discharge (Anterior…
Phase 3 N=332 Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Chronic Rhinosinusitis
Primary: Change From Baseline in Symptoms as Measured by a Composite Score for Each Symptom of Nasal Congestion, Facial Pain or Pressure Sensation, and Nasal Discharge (Anterior…
Phase 3 N=410 Efficacy and Safety Study of Benralizumab for Patients With Severe Nasal Polyposis
Nasal Polyposis
Primary: Change From Baseline in Total NPS at Week 40 — -0.36; 0.17 Score on a scale — p=<0.0001
Phase 2 N=14 Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
Rhinosinusitis · Chronic Polyposis
Primary: Change of Inflammation of the Nasal Mucosa and Paranasal Sinus — -2; -0.8 units on a scale
N/A N=27 Qualitative Analysis of Subject Experience of Nasal Polyps
Nasal Polyps
Primary: Number of Participants Who Reported Primary Symptoms — 27; 27; 25; 24 Participants
Phase 3 N=25 Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
Chronic Rhinosinusitis
Primary: Change in Rhinosinusitis Disability Index (RSDI) Score — -8.000; -14.82 units on a scale — p=0.505